5350-86-7Relevant articles and documents
GUANIDINE DERIVATIVES AS TRPC MODULATORS
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Page/Page column 134-135, (2014/02/16)
The present invention is directed to guanidine derivatives as inhibitors of transient receptor potential canonical channels (TRPC channels), in particular TRPC3 and/or TRPC6 and/or TRPC7 activity, more particularly TRPC6 activity. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders mediated by TRPC channels (Formula (I))
Lithium enediolates and dienediolates of carboxylic acids in synthesis: Alkylation with secondary halides
Brun, Eva M.,Gil, Salvador,Mestres, Ramon,Parra, Margarita
, p. 15305 - 15320 (2007/10/03)
High yields in the alkylation of dianions of α,β-unsaturated carboxylic acids with secondary halides can be obtained despite elimination reactions occurring. α-Regioselectivity for the alkylation of but-2-enoic acids (1-4) is seldom obtained. Although dou