53500-38-2Relevant academic research and scientific papers
Novel 2-aminomethyl-4-,6-dihalogenphenol derivatives and methods for the preparation thereof
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, (2008/06/13)
2-AMINOMETHYL-4,6-DIHALOGENPHENOL DERIVATIVES AND SALTS THEREOF WITH PHYSIOLOGICALLY ACCEPTABLE ACIDS OR BASES HAVING THE FORMULA: STR1 wherein X is the same halogen in both positions, R1 is a hydrogen atom or a lower alkyl group, R2 is an alkyl, cycloalkyl, aryl or aralkyl group, or R1 and R2 together with the nitrogen atom may form a saturated heterocyclic ring, which ring may be interrupted by an oxygen, nitrogen or sulfur atom, R3 is a hydrogen atom, an alkyl, alkoxyalkyl, carboxyalkyl, carbamylalkyl, aralkyl, acyl or sulfonyl group or a base radical, e.g. an alkali metal atom, and R3 " is a cyanoalkyl, hydroxyalkyl, carbalkoxy-alkyl, N,N-dialkylcarbamyl, N-alkylcarbamyl-alkyl or N,N-dialkylcarbamylalkyl group, are useful as diuretics and saluretics; some derivatives possess secretolytic activity.
Novel 2-amino methyl-4,6-dihalogenphenol derivatives and methods for the preparation thereof
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, (2008/06/13)
2-AMINOMETHYL-4,6-DIHALOGENPHENOL DERIVATIVES AND SALTS THEREOF WITH PHYSIOLOGICALLY ACCEPTABLE ACIDS OR BASES HAVING THE FORMULA: STR1 wherein X is the same halogen in both positions, R1 is a hydrogen atom or a lower alkyl group, R2 is an alkyl, cycloalkyl, aryl or aralkyl group, or R1 and R2 together with the nitrogen atom may form a saturated heterocyclic ring, which ring may be interrupted by an oxygen, nitrogen or sulfur atom, R3 is a hydrogen atom, an alkyl, alkoxyalkyl, carboxyalkyl, carbamylalkyl, aralkyl, acyl or sulfonyl group or a base radical, e.g. an alkali metal atom, and R3 " is a cyanoalkyl, hydroxyalkyl, carbalkoxy-alkyl, N,N-dialkylcarbamyl, N-alkylcarbamyl-alkyl or N,N-dialkylcarbamylalkyl group, are useful as diuretics and saluretics; some derivatives possess secretolytic activity.
