53501-68-1Relevant academic research and scientific papers
Rhodium-Catalyzed Dehydrogenative Annulation of N-Arylmethanimines with Vinylene Carbonate for Synthesizing Quinolines
Hu, Yan,Nan, Jiang,Yin, Jiacheng,Huang, Guanjie,Ren, Xin,Ma, Yangmin
supporting information, p. 8527 - 8532 (2021/11/13)
Here we report a novel Rh-catalyzed C-H/C-H alkenylation of N-arylmethanimines with vinylene carbonate acting as a vinylene unit. Forty examples of C3,C4-nonsubstituted quinolines were achieved from commercially available starting materials. This identified process features an exceedingly simple system, a lower loading of catalyst, and the capacity for postfunctionalization with bioactive molecules.
Design and stereoselective synthesis of novel β-lactone and β-lactams as potent anticancer agents on breast cancer cells
Rashidi, Mahnoosh,Islami, Mohammad Reza,Esmaeili-Mahani, Saeed
, p. 835 - 841 (2018/01/22)
To produce a novel class of anticancer compounds, an efficient method for synthesizing novel β-lactone and β-lactam frameworks was developed based on the reaction of a new ketene with C=O and C=N bonds. Functionalized 2-azetidinones were efficiently synthesized by employing 2,4-dichlorophenoxylketene, which was generated in situ. The reaction of the ketene with aldehydes was not successful and in all cases except for 4-nitrobenzaldehyde, a rearranged dimer of the ketene was obtained as a lactone. Anticancer cellular activity of all new β-lactams and lactones on breast cancer cells was studied. All new synthesized compounds exhibited potential anticancer activity which may guarantee their future application in moderate chemotherapy.
An efficient method for the synthesis of indolo[3,2-c]quinoline derivatives catalyzed by iodine
Zhou, Yujing,Zhang, Meimei,Yin, Mingyue,Wang, Xiangshan
, p. 237 - 242 (2013/08/24)
The reaction of Schiff base and indole catalyzed by iodine in DMA, subsequently treated with DDQ, gave indolo[3,2-c]quinoline derivatives in good yields. The structure of 3e was confirmed by X-ray diffraction analysis. The reaction of Schiff base and indo
A stereoselective Povarov reaction leading to exo-tetrahydroindolo[3,2-c] quinoline derivatives catalyzed by iodine
Wang, Xiang-Shan,Yin, Ming-Yue,Wang, Wei,Tu, Shu-Jiang
experimental part, p. 4811 - 4818 (2012/09/22)
We report an iodine-catalyzed Povarov reaction using indole as dienophile carried out in toluene at room temperature. This three-component reaction, coupling an aldehyde, an amine, and an indole, proved to be an efficient method for synthesizing exo-indol
Reaction of β-Arylidennaphthylamines with 4-Hydroxycoumarin. A Correction in Structural Assignment of the Product. III.
Martinez, Roberto,Cortes, Eduardo,Toscano, Ruben A.,Alfaro, L. Josue
, p. 1273 - 1276 (2007/10/02)
The reaction of 4-hydroxycoumarin with β-arylidennaphthylamines constitutes a convenient synthetic route to the hitherto unknown 2H-benzobenzopyranoquinolin-2-one, VI.The X-ray crystallography data conform with the present benzopyranoq
