5352-88-5

Usage

InChI:InChI=1/C8H9ClN2O/c1-10-8(12)11-7-4-2-6(9)3-5-7/h2-5H,1H3,(H2,10,11,12)

Upstream product

• 13256-32-1 1,3 dimethyl 1 nitrosourea 
• 106-47-8 4-chloro-aniline 
• 624-83-9 methyl isocyanate 
• 25546-06-9 N'-(4-chloro-phenyl)-N-formyl-N-methyl-urea 
• 150-68-5 monuron 
• 104-12-1 p-chlorphenylisocyanate 
• 74-89-5 methylamine 
• 372-09-8 cyanoacetic acid 
• 598-50-5 N-Methylurea 
• 120-82-1 1,2,4-Trichlorobenzene 
• 873-73-4 4-n-chlorophenylacetylene 

Downstream Products

• 31949-03-8 C₉H₈Cl₂N₂O₂ 
• 25355-61-7 1-(4-chlorophenyl)-3-isopropyl-3-nitrosourea 
• 110396-88-8 C₈H₈ClN₃O₂ 
• 126381-33-7 3-(4-Chloro-phenyl)-1-(2-cyano-acetyl)-1-methyl-urea 
• 36743-37-0 3-(4-chloro-phenyl)-5-methyl-1,1-dioxo-1λ⁶-[1,3,5]thiadiazinan-4-one 
• 36744-20-4 3-(4-chloro-phenyl)-5-methyl-1-oxo-1λ⁴-[1,3,5]thiadiazinan-4-one 
• 110396-85-5 isoamyl 4-chlorophenylcarbamate 
• 7629-18-7 6-amino-1-(4-chloro-phenyl)-3-methyl-1H-pyrimidine-2,4-dione 
• 126381-39-3 6-Amino-1-(4-chloro-phenyl)-3-methyl-5-nitroso-1H-pyrimidine-2,4-dione 
• 116571-28-9 1-(4-Chloro-phenyl)-3-methyl-imidazolidine-2,4,5-trione 
• 36744-17-9 3-(4-chloro-phenyl)-5-methyl-[1,3,5]thiadiazinan-4-one 

Relevant academic research and scientific papers

Splitting a Substrate into Three Parts: Gold-Catalyzed Nitrogenation of Alkynes by C-C and C≡C Bond Cleavage

A gold-catalyzed nitrogenation of alkynes for the synthesis of carbamides and amino tetrazoles through C-C and C≡C bond cleavages is described. A diverse set of functionalized carbamide and amino tetrazole derivatives were selectively constructed under mild conditions. The chemoselectivity can be easily switched by the selection of the acid additives. The reaction is characterized by its broad substrate scope, direct construction of high value products, easy operation under air, and mild conditions at room temperature. This chemistry provides a way to transform alkynes by splitting the substrate into three parts.

Kinetic and analytical study of the photo-induced degradation of monuron by nitrates and nitrites under irradiation or in the dark

The photo-induced transformation of monuron (3-(4-chlorophenyl)-1,1 dimethylurea) was investigated in an aqueous solution containing nitrates and nitrites at 310 nm and 365 nm, respectively. In both NO3- and NO2-/sup

Mineralisation of Monuron photoinduced by Fe(III) in aqueous solution

The degradation of Monuron (3-(4-chlorophenyl)-1,1-dimethylurea) photoinduced by Fe(III) in aqueous solution has been investigated. The rate of degradation depends on the concentration of Fe(OH)2+, the most photoreactive species in terms of su

1-arylpyrimidine derivatives and pharmaceutical use thereof

The present invention relates to 1-arylpyrimidine derivatives represented by general formula (I): STR1 wherein R1 is H, alkyl or aralkyl; Ar is 1-naphthyl, or a substituted or unsubstituted phenyl group; R4 is a substituted phenyl, a substituted styryl, 1-methylcyclohexyl, 4-methylcyclohexyl, 4-oxo-4H-pyran-2-yl or 2-oxo-2H-pyran-5-yl group; R5 and R6 are each independently H or alkyl; R3 is H, and R7 and R8 are combined together to be oxo, or else R3 and R7 are combined together to be another direct bond, and R5 and R8 are combined together to be a direct bond, or pharmaceutically acceptable salts thereof; and methods for treating allergic diseases with such compounds.

Process for the preparation of pure, unsymmetrically disubstituted ureas

Process for the preparation of pure, unsymmetrically disubstituted ureas of the general formula STR1 in which R denotes a phenyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy, aryloxy or trifluoromethyl groups, an oxazolyl, isoxazolyl, thiazolyl, isothiazolyl, benzoxazolyl or benzothiazolyl radical which is unsubstituted, or monosubstituted or polysubstituted by halogen atoms or alkyl, alkoxy or trifluoromethyl groups and R1 and R2 independently of one another denote a hydrogen atom or an alkyl group, where R1 and R2 are not simultaneously hydrogen or R1 and R2 together denote a butylene or pentylene group, by reaction of an N-alkyl- or N,N-dialkylurea with an unsubstituted or substituted arylamine or a heterocyclic amine in the presence of that amine which is already present in the starting material, the respective N-alkyl- or N,N-dialkylurea.

Reactions of N- or N'-Blocked N-acylureas with Amines

In order to make reactions of N-acylureas with amines more selective N- or N'-blocked derivatives were prepared.Their fragmentation was examined.

PREPARATION AND PROPERTIES OF 3-ALKYL-i-ARYLNITROSOUREAS AND RELATED COMPOUNDS

Nitrosation of 3-alkyl-1-arylureas was investigated with sodium nitrite in 99percent formic acid or with isoamyl nitrite in chloroform.The preparation of 3-alkyl-1-aryl-1-nitrosoureas was effectively performed by using isoamyl nitrite in the absence of acids, since the 1-nitrosoureas were isomerized to the 3-nitroso isomers by acids.The carbon-13 nuclear magnetic resonance and infrared spectral properties of the products were examined and their structural features are discussed.It was found that 3-alkyl-1-aryl-1-nitrosoureas decomposed to form alkyl isocyanates and 3-alkyl-1-(2-nitroaryl)ureas in carbon tetrachloride. 1,3-Rearrangement and transnitrosation also took place in this solvent.Keywords - 3-alkyl-1-arylnitrosourea; 3,3-diethyl-1-tolyl-1-nitrosourea; N-nitrosourea; nitrosation; 1,3-rearrangement; isomerization; transnitrosation; nitration