53544-74-4Relevant academic research and scientific papers
Straightforward synthesis of PET tracer precursors used for the early diagnosis of Alzheimers disease through Suzuki-Miyaura cross-coupling reactions
Bort, Guillaume,Sylla-Iyarreta Veitía, Maité,Ferroud, Clotilde
, p. 7345 - 7353 (2013/08/23)
In positron emission tomography [11C]PIB, Pittsburgh Compound-B, is currently the most widely used radiopharmaceutical for the early diagnosis of Alzheimer's disease. Synthetic routes for the preparation of the precursor of [11C]PIB are reported in the literature. These strategies require multiple steps and the use of protecting groups. This paper describes a simple one-step synthesis of the precursor of [11C]PIB through a Suzuki-Miyaura coupling reaction using thermal conditions or microwave activation. These methods were successfully applied to the synthesis of various 2-arylbenzothiazole and 2-pyridinylbenzothiazole compounds including [ 18F] precursor derivatives of PIB containing a nitro function.
NOVEL INHIBITORS OF HEPATITIS C VIRUS REPLICATION
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Page/Page column 308, (2011/07/06)
The embodiments provide compounds of the general Formulae I, II, III, IV, or V as well as compositions, including pharmaceutical compositions, comprising a subject compound. The embodiments further provide treatment methods, including methods of treating a hepatitis C virus infection and methods of treating liver fibrosis, the methods generally involving administering to an individual in need thereof an effective amount of a subject compound or composition.
Synthesis and antitumor evaluation of novel derivatives of 6-amino-2-phenylbenzothiazoles
Racane, Livio,Stojkovic, Ranko,Tralic-Kulenovic, Vesna,Karminski-Zamola, Grace
, p. 325 - 333 (2007/10/03)
Novel derivatives of 6-amino-2-phenylbenzothiazole bearing different substituents (amino, dimethylamino or fluoro) on the phenyl ring were prepared as the corresponding hydrochloride salts. 6-Nitro-2-(substituted-phenyl) benzothiazoles (1-6) were synthesi
