53545-94-1

Upstream product

• 6940-78-9 4-chlorobutyl bromide 
• 78-82-0 Isobutyronitrile 
• 50654-53-0 2-lithio-2-methylpropionitrile 
• 110-56-5 1,4-dichlorobutane 

Downstream Products

• 55897-65-9 2,2-dimethylhexanenitrile 
• 91267-12-8 2,2-Dimethyl-6-methylsulfon-cyclohexanon 
• 10219-83-7 3,3-dimethyl-2-oxocyclohexanecarbonitrile 
• 140660-12-4 6-(4-acetyl-2-ethyl-5-hydroxyphenoxy)-2,2-dimethylhexanenitrile 
• 140660-16-8 CGS 23167 
• 738606-46-7 ETC-1002 

Relevant academic research and scientific papers

Preparation method 8 -hydroxy -2, 2, 14 and 14 -tetramethyl-pentadecanedioic acid

The invention relates to a preparation method of 8 - hydroxyl -2, 2, 14 and 14 -tetramethyldodecanedioic acid. The method utilizes isobutyronitrile (II) and 1, 4 - dihalogenated butane as raw materials to obtain 2, 2 -dimethyl -6 -halogenated n-hexanenitrile, then with 1, 3 -di P-substituted acetone (substituent P) COOR. CN Or CONH2 Through substitution reaction, hydrolysis, acidification and decarboxylation, 8 - oxo -2, 2, 14, 14 - tetramethyldodecanedioic acid, and a boric acid reducing agent are subjected to reduction reaction, and then hydrolyzed and acidified to obtain a target product. To the invention, isobutyronitrile is adopted as an initial raw material, and raw materials are cheap and easily available. Easy operation, reaction conditions easily realize. The system is safe, environment-friendly and small in wastewater generation amount. The method has the advantages of low cost, high reaction selectivity, less byproducts, high target product yield and purity and suitability for green industrial production.

SEMICONDUCTING COMPOSITIONS COMPRISING SEMICONDUCTING POLYMERS

A semiconducting composition comprising a semiconducting polymer and a semiconducting non-polymeric polycyclic compound, wherein the semiconducting polymer comprises units of A and/or B: wherein R1, R2, R5, R6, R7, R8, x, y, p, q, r, R3, R4, R9, R10 and R11 have any of the meanings defined in the description.

Discovery and SAR study of hydroxyacetophenone derivatives as potent, non-steroidal farnesoid X receptor (FXR) antagonists

Compound 1 (IC50 = 35.2 ± 7.2 μM), a moderate FXR antagonist was discovered via high-throughput screening. Structure-activity relationship studies indicated that the shape and the lipophilicity of the substituents of the aromatic ring affect the activity dramatically, increasing the shape and the lipophilicity of the substituents of the aromatic ring enhances the potency of FXR antagonists. Especially, when the OH at C2 position of the aromatic ring was replaced by the OBn substituent (analog 2b), its activity could be improved to IC50 = 1.1 ± 0.1 μM. Besides, the length of the linker and the tetrazole structure are essential for retaining the activity.

Cascade condensation, cyclization, intermolecular dipolar cycloaddition by multi-component coupling and application to a synthesis of (±)-crispine A

A general approach for the synthesis of various nitrogen-containing heterocyclic compounds is described using an intermolecular dipolar cycloaddition reaction of azomethine ylides and nitrones. Stabilized and non-stabilized azomethine ylide dipoles or the related nitrones were generated by condensation of 4-, 5- or 6-halo-aldehydes with a readily available amino-acid, amino-ester or hydroxylamine to give an imine followed by cyclization and either decarboxylation or loss of a proton. After intermolecular cycloaddition with an activated dipolarophile, bicyclic or polycyclic (if the ylide dipole and/or dipolarophile contain a ring) amines were produced. A short synthesis of the alkaloid (±)-crispine A was achieved based on this tandem/domino 3-component coupling chemistry.