53546-06-8

Upstream product

• 35021-93-3 N-(1-phenylethylidene)prop-2-en-1-amine 
• 98-86-2 acetophenone 
• 19433-17-1 acetophenone O-acetyloxime 
• 123-38-6 propionaldehyde 
• 122712-52-1 phenyl-1 amino-1 butadiene-2,3 
• 591-50-4 iodobenzene 

Relevant academic research and scientific papers

Synthesis of Poly-Substituted Pyridines via Noble-Metal-Free Cycloaddition of Ketones and Imines

An eco-friendly and noble-metal-free formal [4+2] cycloaddition reaction was developed for the efficient synthesis of biologically interesting poly-substituted pyridines from easily available ketones and imines, whereby two sequential C?C bonds are formed. The given approach features a unique synthetic strategy of imines and ketones with wide substrate scope, good functional group tolerance, mild conditions and operational simplicity, which represents a more direct pathway to synthesize poly-substituted pyridines than traditional methods.

2-ethyl-4, 6-disubstituted pyridine compound and preparation method thereof

The invention discloses a 2-ethyl-4, 6-disubstituted pyridine compound and a synthesis method thereof. The structural formula of the compound is as shown in the specification, wherein R1 and R2 are respectively phenyl, 2-methylphenyl, 3-methylphenyl, 4-methylphenyl, 3-chlorphenyl, 4-methoxyphenyl, 4-fluorophenyl, furan or pyridine. According to the method, alkenyl imine and ketone are used as rawmaterials, a series of polysubstituted pyridine compounds are efficiently constructed through a cycloaddition reaction without metal participation, the raw materials are simple and easily available, the reaction conditions are mild, the substrate expansibility and functional group compatibility are better, and the yield is medium to excellent. The 2-ethyl-4, 6-disubstituted pyridine compound synthesized by applying the method has a relatively good application prospect in the fields of scientific research and industrial production.

Synthesis of symmetrical pyridines by iron-catalyzed cyclization of ketoxime acetates and aldehydes

A novel and facile iron-catalyzed cyclization of ketoxime acetates and aldehydes for the green synthesis of substituted pyridines has been developed. In the presence of a FeCl3 catalyst, this reaction exhibited a good functional group tolerance to produce 2,4,6-triarylsubstituted symmetrical pyridines in high yields in the absence of any additive. A gram-scale reaction sequence was performed to demonstrate the scaled-up applicability of this synthetic method.

Synthesis of multisubstituted pyridines

By utilizing amino allenes, aldehydes, and aryl iodides as readily available building blocks, a simple and modular synthesis of multisubstituted pyridines with flexible control over the substitution pattern has been achieved. The method employs a two-step