53546-78-4

Usage

Physical state

Colorless liquid

Uses

a. Fragrance ingredient in perfumes and cosmetics
b. Flavor enhancer in food products
c. Solvent in industrial applications

Synthesis

Reaction of 3-methyl-3-buten-1-ol with 1,2,5-trimethylbenzene in the presence of an acid catalyst

Aroma

Sweet, floral scent

Safety precautions

a. Harmful if ingested or inhaled
b. Can cause skin and eye irritation

Handling

Handle with care to avoid ingestion, inhalation, or skin/eye contact

Upstream product

• 697-82-5 2,3,5-trimethylphenol 
• 107-05-1 3-chloroprop-1-ene 
• 106-95-6 allyl bromide 

Downstream Products

• 6626-30-8 2,3,5-trimethyl-6-prop-2-en-1-ylphenol 
• 1243545-66-5 1-(4-methoxyphenyl)-4-(2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl)piperazine 
• 1243545-69-8 1-(4-methoxyphenyl)-4-[(2S)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine 
• 1243545-67-6 1-(4-methoxyphenyl)-4-[(2R)-2,4,6,7-tetramethyl-2,3-dihydro-1-benzofuran-5-yl]piperazine 

Relevant academic research and scientific papers

Discovery of Benzofuran Derivatives that Collaborate with Insulin-Like Growth Factor 1 (IGF-1) to Promote Neuroprotection

A series of benzofuran derivatives with neuroprotective activity in collaboration with IGF-1 was discovered using a newly developed cell-based assay involving primary neural cells prepared from rat hippocampal and cerebral cortical tissues. A structure-ac

Benzofuran derivatives

The present invention provides a compound represented by the following formula (I): wherein: Ring A represents an optionally substituted piperazine ring, an optionally substituted morpholine ring, or an optionally substituted homopiperazine ring;R1 and R2 are the same or different from each other, and represent a hydrogen atom or optionally substituted lower alkyl;R3 and R4 are the same or different from each other, and represent a hydrogen atom or halogenated or non-halogenated lower alkyl;R5 to R7 are the same or different from each other, and represent a hydrogen atom, hydroxy, optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkoxy, optionally substituted cycloalkyl, optionally substituted aryl, an optionally substituted aromatic heterocyclic ring, optionally substituted amino, or acyl; and represents a single bond or double bond, or a salt thereof.

Thermodynamic, spectroscopic, and density functional theory studies of allyl aryl and prop-1-enyl aryl ethers. Part 1. Thermodynamic data of isomerization

A chemical equilibration study of the relative thermodynamic stabilities of seventy isomeric allyl aryl ethers (a) and (Z)-prop-1-enyl aryl ethers (b) in DMSO solution has been carried out. From the variation of the equilibrium constant with temperature the Gibbs energies, enthalpies, and entropies of isomerization at 298.15 K have been evaluated. Because of their low enthalpies, the (Z)-prop-1-enyl aryl ethers are strongly favored at equilibrium, the Gibbs energies of the a→b isomerization ranging from -12 to -23 kJ mol-1. The entropy contribution is negligible in most reactions, but occasionally small positive values less than +10 J K-1 mol-1 of the entropy of isomerization are found. The equilibration studies were also extended to involve two pairs of related isomeric ethers with a Me substituent on C(2) of the olefinic bond. The Me substituent was found to increase the relative thermodynamic stability of the allylic ethers by ca. 3.4 kJ mol-1.