53555-10-5Relevant academic research and scientific papers
Mechanochemical synthesis of phthalimides with crystal structures of intermediates and products
Cola?o, Melwin,Dubois, Jean,Wouters, Johan
, p. 2523 - 2528 (2015/03/18)
A series of phthalimides have been successfully synthesized in the solid state by grinding (or kneading) of substituted phthalic anhydride and aniline derivatives. Selected products and intermediates were crystallized and characterized by crystallography leading to a potential rationale for the solid-state reactivity that suggests that co-crystals could serve as intermediates. This journal is
Synthesis of hydroxylactams and esters derived from thalidomide and their antitumor activities
Sun, Guanglong,Liu, Xiangchao,Zhou, Heng,Liu, Zenglu,Mao, Zhenmin
, p. 1337 - 1342 (2014/06/09)
A novel and convenient route for the synthesis of a series of thalidomide derivatives is described. Compound 2 was cyclized with different amines under alkaline condition to obtain 4-nitro substituted phthalimidines 3a-d. Hydroxylactams 4a-d were produced via bromination and hydroxylation. Different acyl chlorides were reacted with hydroxylactams to provide the desired esters 5a-d. All compounds were evaluated by MTT assay for their inhibitory activities against HCT-116, MG-63, MCF-7, HUVEC and HMVEC cell lines in vitro. Most of them showed no obvious cytotoxic effect on normal human cells, compounds 4a-d, 5a2, 5a4, 5a5, 5b2, 5c2 and 5d2 exhibited potent antitumor activities, among which compounds 5a2 and 5b2 were more effective than 5-FU.
An expedient method to the synthesis of N-substituted 1H-isoindole-1,3(2H)- diones
Nikpour, Farzad,Mogaddam, Baran Mohammadi
experimental part, p. 2289 - 2292 (2011/04/17)
The synthesis of N-substituted 1H-isoindole-1,3-(2H)-diones is described from the reaction of cyclic anhydrides with Schiff bases as suitable replacing substrates instead of the corresponding amines. The Japan Institute of Heterocyclic Chemistry.
