53557-98-5

Upstream product

• 1123-49-5 3,5-dimethyl-4-nitroisoxazole 
• 89-98-5 2-chloro-benzaldehyde 
• 300-87-8 3,5-dimethyl-1,2-oxazole 
• 123-54-6 acetylacetone 

Downstream Products

• 103806-27-5 2-acetyl-3-(2-chlorophenyl)-4-(3-methyl-4-nitroisoxazol-5-yl)butyric acid ethyl ester 
• 79510-71-7 5-(2-Chloro-phenyl)-3'-methyl-4'-nitro-3-phenyl-4,5-dihydro-[4,5']biisoxazolyl 
• 86461-84-9 5-[1,2-Dibromo-2-(2-chloro-phenyl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 869586-75-4 4-(2-chlorophenyl)-5-(3-methyl-4-nitroisoxazol-5-yl)pentan-2-one 
• 98239-36-2 5-[2-(2-Chloro-phenyl)-2-(3,5-dimethyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 98239-46-4 5-[2-(2-Chloro-phenyl)-2-(3,5-dimethyl-1-phenyl-1H-pyrazol-4-yl)-ethyl]-3-methyl-4-nitro-isoxazole 
• 78636-39-2 C₁₇H₁₆ClN₃O₄ 
• 1021951-89-2 (1R,2S)-1-(2-chlorophenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)-ethane-1,2-diol 
• 53558-05-7 5-(2-chloro-styryl)-3-methyl-isoxazol-4-ylamine 
• 1262968-93-3 1-(2-chloro-phenyl)-2-(3-methyl-4-nitro-isoxazol-5-yl)ethanesulfonic acid 
• 1316316-21-8 C₂₉H₂₇ClN₄O₇ 
• 1242340-73-3 C₂₇H₂₁ClN₆O₇ 
• 1380544-35-3 5-(2-chlorophenethyl)-3-methyl-4-nitroisoxazole 
• 1459161-39-7 tert-butyl (2S)-2-((1R)-1-(2-chlorophenyl)-2-(3-methyl-4-nitroisoxazol-5-yl)ethyl)-5-oxo-2,5-dihydro-1H-pyrrole-1-carboxylate 

Relevant academic research and scientific papers

Multicomponent synthesis of spiroisoxazolines

A three-component one-pot procedure (3-MCR) was developed to assemble the spiroisoxazoline nucleus from commercially available materials. This new methodology affords the title compounds in high yields and without the use of chromatography.

Phosphine-Catalyzed [3 + 2] Annulation of Morita-Baylis-Hillman Carbonates with Isoxazole-Based Alkenes

A phosphine-catalyzed [3 + 2] annulation of Morita-Baylis-Hillman (MBH) carbonates with 3-methyl-4-nitro-5-styrylisoxazoles has been developed to afford various multifunctional isoxazoles in moderate to good yields with moderate to excellent diastereoselectivities. With a spirocyclic chiral phosphine as the catalyst, up to 89% ee was obtained.

An efficient solvent-free synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using solid nano-titania

Abstract: An efficient and solvent-free procedure for the synthesis of 3-methyl-4-nitro-5-styrylisoxazoles using nano-titania as solid support and recyclable catalyst is presented. This method provides clean, simple, solvent-free and useful alternative to

Organocatalyzed asymmetric vinylogous Michael addition of α,β-unsaturated γ-butyrolactam

Highly efficient asymmetric vinylogous 1,6-Michael addition of α,β-unsaturated γ-butyrolactam to 3-methyl-4-nitro-5-alkenyl- isoxazoles and Michael addition to trichloromethyl ketones by using a chiral quinine-derived squaramide organocatalyst were described, giving products with high diastereo- and enantioselectivities (up to >25:1 dr and 96% ee).

Multi-component synthesis and in vitro and in vivo anticancer activity of novel arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides

A three component one-pot protocol has been investigated for the synthesis of arylmethylene bis-isoxazolo[4,5-b]pyridine-N-oxides 1 from the commercially available materials. The title compounds 1 were also synthesized by a step-wise method and found to b

A fast and highly efficient protocol for synthesis of pyrrolo[2,3-d] isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles using task-specific ionic liquids as catalyst and green solvent

We report a mild, fast, highly efficient and eco-friendly protocol for the green synthesis of pyrrolo[2,3-d]isoxazoles and a new series of novel benzyl bis-pyrrolo[2,3-d]isoxazoles from nitro styrylisoxazoles in SnCl 2-ionic liquid by reductive

Multi-component synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N- oxides

A three component one-pot protocol was investigated for the synthesis of methylene bis isoxazolo[4,5-b]-pyridine-N-oxides from commercially available materials.

Michael additions on isoxazole derivatives under solvent-free conditions

Knoevenagel condensation of 3,5-dimethyl-4-nitro-isoxazole 1 with aromatic aldehydes in solid state in the presence of piperidine gives 3-methyl-4-nitro-5-styryl-isoxazoles 2 in excellent yields within few minutes. Michael addition of active methylene com

Chemistry of Heterocylces: Part VIII - Synthesis of Isoxazolylethylpyrazoles

The base-catalysed addition of acetylacetone to 3-methyl-4-nitro-5-styrylisoxazoles (II) leads to the Michael adducts 3-pentane-2,4-diones (III).These β-diketones (III) undergo cyclization with hydrazine sulphate and phenylhydrazine to furnish pyrazoles (IV) and N-phenylpyrazoles (V), respectively.