53577-98-3

Upstream product

• 67-56-1 methanol 
• 3440-23-1 1-(1-methoxyvinyl)-4-nitrobenzene 
• 603-76-9 1-methylindole 
• 100-19-6 (4-nitrophenyl)ethanone 
• 68970-01-4 α-methoxy-4-nitrostyrene 
• 92670-55-8 Phosphoric acid ethyl ester 1-(4-nitro-phenyl)-vinyl ester 
• 92670-56-9 cyclohexylammonium α-(p-nitrophenyl)vinyl ethyl phosphate 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 100-19-6 (4-nitrophenyl)ethanone 
• 67-56-1 methanol 
• 3440-23-1 1-(1-methoxyvinyl)-4-nitrobenzene 
• 68970-01-4 α-methoxy-4-nitrostyrene 
• 1333519-82-6 (Z)-4-(((1-benzyl-1H-1,2,3-triazol-4-yl)methyl)amino)-1,1,1-trifluoro-4-(4-nitrophenyl)but-3-en-2-one 
• 1283097-05-1 2-amino-5-trifluoromethyl-7-(4-nitrophenyl)-1,8-naphthyridine 
• 868662-47-9 4-[5-hydroxy-3-(4-nitrophenyl)-5-trifluoromethyl-4,5-dihydro-1H-pyrazol-1-yl]-7-chloroquinoline 
• 1372713-46-6 1,1,1-trichloro-4-hydroxy-4-(4-nitrophenyl)-3-buten-2-one 

Relevant academic research and scientific papers

A simple, direct synthesis of 3-vinylindoles from the carbocation-catalysed dehydrative cross-coupling of ketones and indoles. A combined experimental and computational study

A straightforward synthesis of a library of largely new 3-vinylindoles via a clean dehydrative coupling reaction between ketones and indoles has been developed. Highly stable, non-nucleophilic aryl(2-methylindol-3-yl)methylium salts have been used as effi

Rearrangement of Hydroxylated Pinene Derivatives to Fenchone-Type Frameworks: Computational Evidence for Dynamically-Controlled Selectivity

An acid-catalyzed Prins/semipinacol rearrangement cascade reaction of hydroxylated pinene derivatives that leads to tricyclic fenchone-type scaffolds in very high yields and diastereoselectivity has been developed. Quantum chemical analysis of the selecti

Green synthesis method of acetal-type or ketal-type compound

The invention discloses a green synthesis method of an acetal-type or ketal-type compound. A carbonyl compound is used as a raw material, a hydrogen-loaded compound is used as a catalyst, then an alcohol substance is added, a reaction is performed to generate the acetal-type or ketal-type compound. The synthesis method is simple and convenient, is high in conversion rate and yield, is safe and stable, has low toxicity and is easy to operate; the used catalyst is simple to prepare, and is cheap and easy to obtain; the reaction process is mild and efficient; the product is easy to separate and purify; the green synthesis method has a wide substrate application range, can be used for synthesizing acetal and ketal spices, and has potential industrial application value.

For detecting imaging agent of neurological disorders

Imaging agents of formulas (I)-(V) and methods for detecting neurological disorders comprising administering to a patient in need compounds of formulas (I)-(V) capable of binding to tau proteins and β-amyloid peptides are presented herein. The invention also relates to methods of imaging Aβ and tau aggregates comprising introducing a detectable quantity of pharmaceutical formulation comprising a radiolabeled compound of formulas (I)-(V) and detecting the labeled compound associated with amyloid deposits and/or tau proteins in a patient. These methods and compositions enable preclinical diagnosis and monitoring progression of AD and other neurological disorders.

Efficient syntheses of ethyl 2-methylthio-and ethyl 2-benzylthio-6-methyl(aryl)pyrimidine-4-carboxylates and their carboxylic acid derivatives

A simple and efficient procedure for the synthesis of ethyl 2-methylthio-and ethyl 2-benzylthio-6-methyl(aryl)-pyrimidine-4-carboxylates and their corresponding acid derivatives is reported. The products are obtained in good yields via the cyclocondensation reaction of ethyl 4-alkoxy-2-oxo-4-methyl(aryl)-but-3-enoates with 2-methylisothiourea sulfate or 2-benzylisothiourea hydrochloride, under mild, basic, aqueous conditions.

A new generation of aprotic yet Bronsted acidic imidazolium salts: Low toxicity, high recyclability and greatly improved activity

Catalysts which have low antimicrobial toxicity and are aprotic, yet which can act as Bronsted acidic catalysts in the presence of protic additives have been developed. The catalysts are recyclable, considerably more active (i.e. can be used at 10-50 times lower loadings) and of broader scope than their antecedent generation.

The catalytic versatility of low toxicity dialkyltriazolium salts: In situ modification facilitates diametrically opposed catalysis modes in one pot

The ability of triazolium salts to serve as a precatalyst for both an acid and a powerful base/nucleophile (controlled by additives) has been exploited in a process characterised by a unique in situ catalyst modification strategy. The Royal Society of Chemistry 2013.

ClickEnam. 1. Synthesis of novel 1,4-disubsituted-[1,2,3]-triazole-derived β-aminovinyl trifluoromethylated ketones and their copper(II) complexes

The copper(I) catalyzed cycloaddition reaction of N-Boc propargyl amine (dipolarophile) 1 with benzyl azide (1,3-dipole) 2 was found to proceed smoothly in t-BuOH/H2O at room temperature, to furnish the corresponding 1,4-disubstituted-[1,2,3]-triazole-derived N-Boc amine 3 in good yield. Deprotection of 3 with trifluoroacetic acid and addition of the trifluoroacetate salt 4 in the presence of triethylamine, with a series of methoxyvinyl(trifluoromethyl)ketones 10-14, gave the corresponding β-aminovinyl trifluoromethylated ketones 15-19 in moderate to good yields. Two copper(II) complexes, one monomer and one dimer with chlorine double bridge, 20 and 21, respectively, were also prepared and their crystal structure determined. β-Aminovinyl trifluoromethylated ketones 15-17 and complexes 20 and 21 have been screened as potential antifungal agents and the antimalarial activity of 15 and 16 were tested against two Plasmodium falciparum strains (3D7 and W2).

Pyridinium ion catalysis of carbonyl protection reactions

Aprotic pyridinium ions incorporating electron-withdrawing substituents on the aromatic ring are powerful catalysts for the acetalization of aldehydes and the formation of dithianes, dithiolanes, dioxanes, and dioxolanes. Under optimum conditions the best catalyst can be used at a loading as low as 0.1 mol% and can outperform a Bronsted acid catalyst with a pka of 2.2. Georg Thieme Verlag Stuttgart.

Unexpected catalysis: Aprotic pyridinium ions as active and recyclable Bronsted acid catalysts in protic media

(Chemical Equation Presented) Simple pyridinium salt derivatives have been (rather unexpectedly) shown to promote highly efficient acetalization reactions of both aldehydes and ketones at ambient temperature. The optimum catalyst is aprotic, yet it can promote the formation of benzaldehyde dimethyl acetal at 0.1 mol % loading more efficiently than a protic Bronsted acid catalyst with a pKa of 2.2. The process is of wide scope with respect to both the nucleophilic and electrophilic components, and the ionic catalyst can be readily recovered by precipitation and reused without loss of activity.