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All-trans-9-desmethyl-vitamin-A-s?ure, also known as 9-cis-retinoic acid, is a naturally occurring metabolite of vitamin A. It plays a crucial role in various biological processes, including cell differentiation, growth, and development. all-trans-9-Desmethyl-vitamin-A-saeure is structurally similar to retinoic acid, the active form of vitamin A, but with a double bond between carbons 9 and 11, which gives it unique properties. 9-cis-retinoic acid is involved in the regulation of gene expression by binding to retinoic acid receptors, which are part of the nuclear receptor superfamily. These receptors, in turn, modulate the transcription of target genes, thereby influencing numerous physiological functions. The compound has been studied for its potential therapeutic applications, particularly in the treatment of skin conditions and certain types of cancer, due to its ability to influence cell differentiation and proliferation.

5358-27-0

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5358-27-0 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 5358-27-0 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 5,3,5 and 8 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 5358-27:
(6*5)+(5*3)+(4*5)+(3*8)+(2*2)+(1*7)=100
100 % 10 = 0
So 5358-27-0 is a valid CAS Registry Number.

5358-27-0Downstream Products

5358-27-0Relevant academic research and scientific papers

Stereoselective synthesis of all-trans-, (13Z)- and (9-nor)-retinoic acids via Stille reaction

Thibonnet, Jér?me,Abarbri, Mohamed,Duchêne, Alain,Parrain, Jean-Luc

, p. 141 - 143 (2007/10/03)

Stereoselective construction of retinoic acid and certain analogues were achieved through two successive Stille reactions. First, the coupling of (E)- 1,2-bis(tributylstannyl)ethene and (Z)- or (E)-tributylstannyl 3-iodoalk-2- enoates was performed followed by iododestannylation. The second step involved another vinyltin which was synthesised by stannylmetallation of the Negishi dienyne derived from β-ionone.

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