53581-14-9

Usage

Chemical class

Aporphine alkaloids

Natural occurrence

Found in various plant species, including Annonaceae

Traditional use

Used in traditional medicine for their medicinal properties

Pharmacological activity

Studied for potential effects on central nervous system disorders

Specific disorder

Parkinson's disease

Mechanism of action

Dopamine receptor agonist activity

Potential application

Treatment of neurological conditions

Additional research

May have potential applications in drug development and treatment of other diseases
This list provides a concise overview of the key properties and information about 11-Methoxy-N-n-propylnoraporphine, as described in the material.

InChI:InChI=1/C20H23NO/c1-3-11-21-12-10-14-6-4-8-16-19(14)17(21)13-15-7-5-9-18(22-2)20(15)16/h4-9,17H,3,10-13H2,1-2H3

Upstream product

• 53581-06-9 1-(2-amino-3-methoxybenzyl)-2-propyl-1,2,3,4-tetrahydroisoquinoline 
• 83207-96-9 (R)-(-)-10-O-(1-phenyltetrazol-5-yl)-11-methoxy-N-n-propylnoraporphine hydrochloride 
• 121617-51-4 (R)-(-)-10-O-(1-phenyltetrazol-5-yl)-11-methoxy-N-n-propylnoraporphine 
• 121617-54-7 (R)-(+)-10-O-(1-phenyltetrazol-5-yl)-N-n-propylnorapomorphine 
• 121653-25-6 3-O-(1-phenyltetrazol-5-yl)-N-n-propylnormorphine 
• 466-97-7 normorphine 
• 41590-60-7 N-demethyl-N-propylmorphine 
• 179952-74-0 Trifluoro-methanesulfonic acid (R)-11-methoxy-6-propyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]quinolin-10-yl ester 

Relevant academic research and scientific papers

11-Substituted (R)-aporphines: Synthesis, pharmacology, and modeling of D(2A) and 5-HT(1A) receptor interactions

A series of C11-substituted (R)-aporphines and C11-oxygenated (R)- noraporphines has been synthesized and evaluated for central serotonergic and dopaminergic effects in vitro and in vive. The various C11-substituents were introduced using efficient nickel

5-HT1A-receptor antagonism: N-alkyl derivatives of (R)-(-)-8,11-dimethoxynoraporphine.

Prompted by previous findings that a p-dimethoxy substitution pattern on an aromatic ring permits retention of dopaminergic agonist effects in certain ring systems, catechol derivatives of which are potent dopaminergic agonists, an 8,11-dimethoxy substitu

Synthesis and dopamine agonist and antagonist effects of (R)-(-)- and (S)-(+)-11-hydroxy-N-n-propylnoraporphine

The R-(-) and S-(+) enantiomers of 11-hydroxy-N-n-propylnoraporphine, (R)-3 and (S)-3, were synthesized in six steps from 1-(3-methoxy-2-nitrobenzyl)isoquinoline. Neuropharmacological evaluation of the R and S isomers (by affinity to dopamine receptor sit