53587-11-4

Basic information

• Product Name: L-Tyrosine benzyl ester p-toluenesulfonate
• Synonyms: H-TYR-OBZL P-TOSYLATE;H-TYR-OBZL TOS;H-TYR-OBZL TOSOH;L-TYROSINE BENZYL ESTER 4-TOLUENESULFONATE SALT;L-TYROSINE BENZYL ESTER P-TOLUENESULFONATE;L-TYROSINE BENZYL ESTER P-TOLUENESULFONATE SALT;L-TYROSINE BENZYL ESTER P-TOSYLATE;L-TYROSINE BENZYL ESTER TOSYLATE
• CAS NO: 53587-11-4
• Molecular Formula: C₇H₈O₃S*C₁₆H₁₇NO₃
• Molecular Weight: 443.51
• EINECS: 258-650-8
• Product Categories: Amino Acid Derivatives;Amino Acids;Tyrosine [Tyr, Y];Amino Acids and Derivatives;Amino Acid Benzyl Esters;Amino Acids (C-Protected);Biochemistry;Amino Acid Derivatives;Peptide Synthesis;Tyrosine;Amino Acids;I - Z;Modified Amino Acids
• Mol File: 53587-11-4.mol
• Article Data: 5

Chemical Properties

• Melting Point: 177 °C
• Boiling Point: 671.3 °C at 760 mmHg
• Flash Point: 359.8 °C
• Appearance: /Solid
• Vapor Pressure: 2.63E-08mmHg at 25°C
• Refractive Index: -13 ° (C=3, MeOH)
• Storage Temp.: −20°C
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: L-Tyrosine benzyl ester p-toluenesulfonate(CAS DataBase Reference)
• NIST Chemistry Reference: L-Tyrosine benzyl ester p-toluenesulfonate(53587-11-4)
• EPA Substance Registry System: L-Tyrosine benzyl ester p-toluenesulfonate(53587-11-4)

Safety Data

• Statements: 22-36/37/38
• Safety Statements: 22/23-26-28-36/37/39
• WGK Germany: 3
• F: 10
• Hazardous Substances Data: 53587-11-4(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

Uses

L-Tyrosine benzyl ester p-toluenesulfonate salt, is used as an important raw material and intermediate used in organic Synthesis, pharmaceuticals, agrochemicals and dyestuff.

InChI:InChI=1/C16H17NO3.C7H8O3S/c17-15(10-12-6-8-14(18)9-7-12)16(19)20-11-13-4-2-1-3-5-13;1-6-2-4-7(5-3-6)11(8,9)10/h1-9,15,18H,10-11,17H2;2-5H,1H3,(H,8,9,10)/t15-;/m0./s1

Upstream product

• 60-18-4 L-tyrosine 
• 100-51-6 benzyl alcohol 
• 104-15-4 toluene-4-sulfonic acid 
• 42406-77-9 L-tyrosine benzyl ester 

Downstream Products

• 204458-92-4 (S)-3-(4-Hydroxy-phenyl)-2-[2-((2R,3R,4R,5R,6R)-3,4,5-tris-benzyloxy-6-benzyloxymethyl-tetrahydro-pyran-2-yl)-acetylamino]-propionic acid benzyl ester 
• 75957-53-8 N-[N-(tert-butoxycarbonyl)-L-valyl]-L-tyrosine benzyl ester 
• 221077-35-6 methyl 4-{[(1S)-2-(benzyloxy)-1-(4-hydroxybenzyl)-2-oxoethyl]amino}-4-oxobutanoate 
• 29739-75-1 N-acetyl-L-tyrosine benzyl ester 
• 1185198-45-1 N-[2-chloro-9-(tetrahydropyran-2-yl)-9H-purin-6-yl]-N-cyclopropylglycyl-L-tyrosine benzyl ester 
• 848210-98-0 (4R,5R)-5-[(S)-1-benzyloxycarbonyl-2-(4-hydroxyphenyl)ethylcarbamoyl]-[1,3]dioxolane-4-carboxylic acid ethyl ester 
• 80622-00-0 H-Val-Tyr-OBzl*TFA 

Relevant articles and documents

Phosphorylation of Tyrosine and Tyr-Thr-Lys Tripeptide with Cyclohexylmethyl- and (Deuteromethyl)phosphonochloridates

Abstract: Methods for phosphorylation of tyrosine and Tyr-Thr-Lys tripeptide with cyclohexylmethyl(deuteromethyl)phosphonochloridates have been developed. These products can be used as reference compounds in the analysis of blood plasma of patients presumably exposed to cyclohexylmethylphosphonofluoridate (cyclosarin) action. Conditions for the separation and purification of the synthesized intermediates by means of chromatography have been determined and optimized, allowing high-purity phosphorylated products at the final stage of the synthesis.

Esterification of unprotected a-Amino acids in ionic liquids as the reaction media

Ionic liquid 1,3-dimethylimidazolium methanesulfonate was used to prepare a-amino acids benzylic esters from unprotected amino acids and benzyl chloride. Esterification of several amino acids was achieved with satisfactory yields: by-products can be removed by a simple work-up procedure to afford the pure product. The described method is simple, mild, rapid and save.

A Simple and Convenient Method for Esterification of Tryptophan and Other Amino Acids

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