535935-84-3

Usage

Uses

Used in Pharmaceutical Research:
5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI) is used as a compound of interest in pharmaceutical research for its potential biological activity. 5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI)'s cyclic amine structure may exhibit properties that are beneficial for the development of new drugs, particularly if it interacts with biological targets in a therapeutically relevant manner.
Used in Organic Synthesis:
In the field of organic synthesis, 5H-Cyclopenta[b]pyridin-5-amine,6,7-dihydro-(9CI) is utilized as a building block or intermediate for the creation of more complex organic molecules. Its unique fused-ring system can be a valuable component in the synthesis of novel compounds with specific chemical or pharmaceutical properties.

InChI:InChI=1/C8H10N2/c9-7-3-4-8-6(7)2-1-5-10-8/h1-2,5,7H,3-4,9H2

Upstream product

• 1071727-80-4 6,7-dihydro-[1]pyrindin-5-one O-methyl-oxime 
• 535935-83-2 (5Z)-6,7-dihydro-5H-cyclopenta[b]pyridin-5-one oxime 

Relevant academic research and scientific papers

Identification of (R)-1-(5-tert-butyl-2,3-dihydro-1H-inden-1-yl)-3-(1H- indazol-4-yl)urea (ABT-102) as a potent TRPV1 antagonist for pain management

Vanilloid receptor TRPV1 is a cation channel that can be activated by a wide range of noxious stimuli, including capsaicin, acid, and heat. Blockade of TRPV1 activation by selective antagonists is under investigation by several pharmaceutical companies in an effort to identify novel agents for pain management. Here we report that replacement of substituted benzyl groups by an indan rigid moiety in a previously described N-indazole-N′-benzyl urea series led to a number of TRPV1 antagonists with significantly increased in vitro potency and enhanced drug-like properties. Extensive evaluation of pharmacological, pharmacokinetic, and toxicological properties of synthesized analogs resulted in identification of (R)-7 (ABT-102). Both the analgesic activity and drug-like properties of (R)-7 support its advancement into clinical pain trials.

SUBSTITUTED FLUOROETHYL UREAS AS ALPHA 2 ADRENERGIC AGENTS

Therapeutic compounds, and methods, compositions, and medicaments related thereto are disclosed herein.

Substituted aryl 1,4-pyrazine derivatives

Substituted aryl 1,4-pyrazine derivatives and their use in treating anxiety disorders, depression and stress related disorders are disclosed.