535937-79-2

Upstream product

• 535937-59-8 4-nitrophenyl-2-(4-trifluoromethylphenylthio)ethyl carbonate 
• 98-56-6 4-chlorobenzotrifluoride 
• 109012-23-9 ethyl 1-methyl-4-nitroimidazole-2-carboxylate 
• 128293-62-9 ethyl 4-amino-1-methylimidazole-2-carboxylate 
• 535937-76-9 1-methyl-4-[2-(4-trifluoromethyl-phenylsulfanyl)ethoxycarbonylamino]-1H-imidazole-2-carboxylic Acid Ethyl Ester 
• 535937-56-5 2-(4-trifluoromethyl-phenylsulfanyl)-ethanol 

Downstream Products

• 535937-85-0 1-methyl-4-[2-(4-trifluoromethyl-benzenesulfonyl)-ethoxycarbonylamino]-1H-imidazole-2-carboxylic acid 

Relevant academic research and scientific papers

Novel compound used as an amino-protecting group, process for preparing the same, and synthetic method of a peptide using the same

The present invention relates to a carbonic acid ester compound of the following formula (1): in which X, Y, and Ar are defined in the specification, which can be easily combined with the amino group of an amino acid or removed therefrom under mild condit

The 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) amino-protecting group: Use in the solid-phase synthesis of pyrrole-imidazole polyamides

The development of the 2-(4-trifluoromethylphenylsulfonyl)ethoxycarbonyl (Tsc) function, a novel base-sensitive amino-protecting group, and its application to the preparation of DNA-binding polyamides are described. Pyrrole-imidazole polyamides were synthesized by an efficient solid-phase method under conditions compatible with Fmoc chemistry using two Tsc-protected amino acids, Tsc-Py-OH 1a and Tsc-Im-OH 1b.