53595-65-6

Usage

Uses

Used in Pharmaceutical Industry:
5-Bromothiophene-2-sulfonamide is used as a synthetic intermediate for the preparation of various 5-arylthiophene-2-sulfonamide derivatives, which are important in the development of pharmaceutical compounds. These derivatives exhibit a range of biological activities, making them valuable for the treatment of various medical conditions.
Used in Chemical Synthesis:
5-Bromothiophene-2-sulfonamide is used as a chemical intermediate for the synthesis of various organic compounds, including:
5-(phenylthio)thiophene-2-sulfonamide
5-bromothiophene-2-sulfonyl acetamide
5-arylthiophene-2-sulfonylacetamide derivatives
These compounds have potential applications in various fields, such as pharmaceuticals, agrochemicals, and materials science.
Used in the Preparation of Specific 5-Arylthiophene-2-Sulfonamides:
5-Bromothiophene-2-sulfonamide is used as a starting material for the preparation of the following 5-arylthiophene-2-sulfonamides:
5-phenylthiophene-2-sulfonamide
5-(3-cyno-5-(trifluoromethyl)phenyl)thiophene-2-sulfonamide
5-(3,5-bis(trifluoromethyl)phenyl)thiophene-2-sulfonamide
5′-chloro-2,2′-bithiophene-5-sulfonamide
5′-methyl-2,2′-bithiophene-5-sulfonamide
5-p-tolylthiophene-2-sulfonamide
5-(4-methoxyphenyl)thiophene-2-sulfonamide
5-(4-chlorophenyl)thiophene-2-sulfonamide
5-(3,4-dichlorophenyl)thiophene-2-sulfonamide
5-(3,5-dimethylphenyl)thiophene-2-sulfonamide
5-(4-chloro-3-fluorophenyl)thiophene-2-sulfonamide
These specific derivatives have potential applications in various industries, including pharmaceuticals, agrochemicals, and materials science, due to their unique chemical properties and potential biological activities.

InChI:InChI=1/C4H4BrNO2S2/c5-3-1-2-4(9-3)10(6,7)8/h1-2H,(H2,6,7,8)

Upstream product

• 55854-46-1 5-bromo-2-thiophenesulfonyl chloride 
• 6339-87-3 2-thiophensulfonamide 
• 1003-09-4 2-bromothiophene 
• 286932-39-6 5-bromothiophene-2-sulphonic acid tert-butylamide 
• 3141-27-3 2,5-dibromothiophen 

Downstream Products

• 519055-62-0 2,4-dichloro-N-[(5-bromo-2-thienyl)sulfonyl]benzenecarboxamide 
• 851262-50-5 5-sulfamoyl-thiophene-2-carbonitrile 
• 935265-57-9 5-(2-(1-(tert-butyldimethylsilyloxy)-7-phenylheptyl)oxazol-5-yl)thiophene-2-sulfonamide 
• 900814-30-4 4-{[5-(aminosulfonyl)-2-thienyl]thio}benzoic acid 
• 63031-97-0 5-[(2-chlorophenyl)thio]thiophene-2-sulfonamide 
• 1620108-51-1 5-(2-formylphenyl)thienyl-2-sulfonamide 
• 1620108-52-2 5-(3-formyl-4-methoxyphenyl)thienyl-2-sulfonamide 
• 1620108-54-4 5-(3-(hydroxymethyl)phenyl)thienyl-2-sulfonamide 
• 1620108-55-5 5-(3-nethoxyphenyl)thienyl-2-sulfonamide 
• 1620108-57-7 5-(4-(benzyloxy)-2-formylphenyl)thienyl-2-sulfonamide 
• 1176724-02-9 methyl 3-(5-sulfamoylthiophen-2-yl)benzoate 
• 1620108-58-8 5-(4-(methoxymethyl)phenyl)thienyl-2-sulfonamide 
• 1620108-59-9 5-(4-chloro-2-methylphenyl)thienyl-2-sulfonamide 
• 1620108-60-2 5-(3-chloro-4-formylphenyl)thienyl-2-sulfonamide 

Relevant academic research and scientific papers

Synthesis, Density functional theory (DFT), Urease inhibition and antimicrobial activities of 5-aryl thiophenes bearing sulphonylacetamide moieties

A variety of novel 5-aryl thiophenes 4a-g containing sulphonylacetamide (sulfacetamide) groups were synthesized in appreciable yields via Pd[0] Suzuki cross coupling reactions. The structures of these newly synthesized compounds were determined using spec

Chemoselective Cleavage of Acylsulfonamides and Sulfonamides by Aluminum Halides

The chemoselective cleavage of C-N bonds of amides, sulfonamides, and acylsulfonamides by aluminum halides is described. AlCl3and AlI3display complementary reactivities toward N-alkyl and N-acyl moieties. N-Alkylacylsulfonamides, sec

2-AMINO-N-(AMINO-OXO-ARYL-LAMBDA6-SULFANYLIDENE)ACETAMIDE COMPOUNDS AND THEIR THERAPEUTIC USE

The present invention pertains generally to the field of therapeutic compounds. More specifically the present invention pertains to certain 2-amino-N-(amino-oxo-aryl-λ6- sulfanylidene)acetamide compounds (referred to herein as ANASIA compounds) that, inter alia, inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase (aaRS) (e.g., bacterial leucyl-tRNA synthetase, LeuRS). The present invention also pertains to pharmaceutical compositions comprising such compounds, and the use of such compounds and compositions, both in vitro and in vivo, to inhibit (e.g., selectively inhibit) bacterial aminoacyl-tRNA synthetase; to treat disorders that are ameliorated by the inhibition (e.g., selective inhibition) of bacterial aminoacyl-tRNA synthetase; to treat bacterial infections; etc.

DIPHENYL SUBSTITUTED THIOPHENE-2-AMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS THEREOF USEFUL AS ANTIMICROBIAL

Compounds or pharmaceutical acceptable salts thereof of Formula (I), in which RM have the meaning described herein and pharmaceutical compositions thereof useful as antimicrobial and/or adjuvant:

Structure-Guided Modification of Heterocyclic Antagonists of the P2Y14 Receptor

The P2Y14 receptor (P2Y14R) mediates inflammatory activity by activating neutrophil motility, but few classes of antagonists are known. We have explored the structure-activity relationship of a 3-(4-phenyl-1H-1,2,3-triazol-1-yl)-5-(aryl)benzoic acid antagonist scaffold, assisted by docking and molecular dynamics (MD) simulation at a P2Y14R homology model. A computational pipeline using the High Throughput MD Python environment guided the analogue design. Selection of candidates was based upon ligand-protein shape and complementarity and the persistence of ligand-protein interactions over time. Predictions of a favorable substitution of a 5-phenyl group with thiophene and an insertion of a three-methylene spacer between the 5-aromatic and alkyl amino moieties were largely consistent with empirical results. The substitution of a key carboxylate group on the core phenyl ring with tetrazole or truncation of the 5-aryl group reduced affinity. The most potent antagonists, using a fluorescent assay, were a primary 3-aminopropyl congener 20 (MRS4458) and phenyl p-carboxamide 30 (MRS4478).

Development of an acyl sulfonamide anti-proliferative agent, ly573636 ? na

The synthesis of 5-bromo-thiophene-2-sulfonic acid 2,4-dichlo- robenzoylamide sodium salt on multikilogram scale is described. The initial clinical supplies were made using carbonyl diimidazole to converge the two fragments. A more efficient acid chloride process has been developed, which also provides better control of impurities and color throughout the synthesis.

SUBSTITUTED BIPHENYL DERIVATIVE

The present invention relates to a biaryl derivative or a pharmacologically acceptable salt thereof having an excellent collagen-synthesis inhibition activity. A biaryl derivative having a structure represented by the following General Formula (I) or a pharmacologically acceptable salt thereof: wherein R1 represents a C6-C10 aryl group which is substituted with one to three group(s) each independently selected from the group consisting of a group defined by formula R-L-, a di-(C1-C6 alkyl)amino group, a di-(C1-C6 alkyl)aminosulfonyl group, a hydroxyaminocarbonyl group, and a halogen atom, and so on; R represents a C1-C6 alkyl group, and so on; L represents a sulfonyl group, an aminosulfonyl group, or a sulfonylamino group, and so on; R2 represents a hydrogen atom, and so on; A represents a group defined by formula (II), (III), or (IV); R3 represents a C1-C6 alkyl group, and so on; and R4 represents a C1-C6 alkyl group, and so on.

PYRAZINE DERIVATIVES AND USE AS PI3K INHIBITORS

The present invention is related to pyrazine derivatives of Formula (I) in particular for the treatment and/or prophylaxis of autoimmune disorders and/or inflammatory diseases, cardiovascular diseases, neurodegenerative diseases, bacterial or viral infections, kidney diseases, platelet aggregation, cancer, transplantation, graft rejection or lung injuries.

2,5-dihalothiophenes in the reaction with chlorosulfonic acid

The mixtures of mono-and dihalothiophenesulfonyl chlorides, formed in the sulfochlorination reaction of 2,5-dichlorothiophene and 2,5-dibromothiophene, were treated with aqueous ammonia and thus converted into mixtures of the corresponding stable thiophenesulfonamides. The structure and composition of the latter were studied by physicochemical methods: GC-MS and 1H, 13C, 1H-13C HSQC, 1H-13C HMBC, and NOESY NMR spectroscopy. As a result of the above chemical transformations, 2,5-dichlorothiophene afforded a mixture of 5-chlorothiophene-2-sulfonamide and 4,5-dichlorothiophene-3-sulfonamide in a roughly 70:30 ratio. In the case of 2,5-dibromothiophene, a mixture of 5-bromothiophene-2-sulfonamide, 4,5-dibromothiophene-3-sulfonamide, and 3,5-dibromothiophene-2-sulfonamide (3:54:43) was formed. Nauka/Interperiodica 2007.

Scandium triflate as an efficient and recyclable catalyst for the deprotection of tert-butyl aryl sulfonamides

A mild and efficient method for deprotection of tert-butyl sulfonamide groups utilizing Sc(OTf)3 as deprotecting reagent has been developed. A variety of tert-butyl aryl sulfonamides used under these conditions gave the corresponding primary sulfonamides in high yields. The Lewis acid catalyst could be fully recovered and reused with maintained activity after the reactions. Copyright Taylor & Francis, Inc.