519055-62-0

Basic information

• Product Name: Tasisulam
• Synonyms: tasisulam;N-(2,4-Dichlorobenzoyl)-5-bromothiophene-2-sulfonamide;Benzamide, N-((5-bromo-2-thienyl)sulfonyl)-2,4-dichloro-;Ly573636;Ly-573636;TS81557;LY573636 (TasisulaM);Tasisulam(Ly-573636
• CAS NO: 519055-62-0
• Molecular Formula: C₁₁H₆BrCl₂NO₃S₂
• Molecular Weight: 415.11
• Product Categories: Inhibitors
• Mol File: 519055-62-0.mol
• Article Data: 9

Chemical Properties

• Appearance: /
• Density: 1.812
• PKA: 3.45±0.10(Predicted)
• CAS DataBase Reference: Tasisulam(CAS DataBase Reference)
• NIST Chemistry Reference: Tasisulam(519055-62-0)
• EPA Substance Registry System: Tasisulam(519055-62-0)

Safety Data

• Hazardous Substances Data: 519055-62-0(Hazardous Substances Data)

Usage

Uses

The sodium salt of Tasisulam has potential antineoplastic activity. Selectively toxic towards tumor cells, tasisulam appears to induce tumor cell apoptosis by a mitochondrial-targeted mechanism involving the loss of mitochondrial membrane potential and induction of reactive oxygen species (ROS).

Upstream product

• 53595-65-6 5-bromo-thiophene-2-sulfonamide 
• 50-84-0 2,4 dichlorobenzoic acid 
• 874-42-0 2,4-dichlorobenzaldeyhde 
• 1152981-12-8 2-bromothiophene-5-sulfonyl azide 
• 89-75-8 2,4-dichlorobenzoyl chloride 

Downstream Products

• 1114547-80-6 N,N'-bis(5-bromothiophen-2-ylsulfonyl)-2,4-dichlorobenzimidamide 

Relevant articles and documents

Facile synthesis of acyl sulfonamides from carboxyic acids using the Mukaiyama reagent

A fast and convenient method using the Mukaiyama reagent was developed to prepare acyl sulfonamides from carboxylic acids and sulfonamides. This methodology is effective for a range of acids and sulfonamides proceeding in moderate to good yields with the

Co-Catalyzed Synthesis of N-Sulfonylcarboxamides from Carboxylic Acids and Sulfonyl Azides

A Co-catalyzed effective synthesis of N-sulfonylcarboxamides from the reaction of carboxylic acids and organic azides in the presence of isocyanide has been developed. The protocol has the advantages of short time, low temperature, and being oxidant-free, which provides a new and simple approach for the synthesis of N-sulfonylcarboxamides in good to excellent yields with a broad substrate scope.

Palladium-Mediated Site-Selective C-H Radio-iodination

The palladium-mediated C-H radio-iodination of arenes using sodium iodide as the primary isotopic source is reported and performed without chemical know-how in 30 min and applied to the synthesis of complex radio-iodinated compounds of biological interest.