53600-18-3

Upstream product

• 943-27-1 4'-t-butylacetophenone 
• 105-39-5 chloroacetic acid ethyl ester 

Downstream Products

• 54017-13-9 ethyl 2-hydroxy-3-(4-tert-butylphenyl)-3-butenoate 
• 59333-58-3 ethyl 3-methyl-3-(4-tert-butylphenyl)-pyruvate 

Relevant academic research and scientific papers

Process for producing 2-hydroxy-3-butenoic acid derivatives

Process for producing a 2-hydroxy-3-butenoic acid derivative having the formula STR1 wherein R1 is an aliphatic, alicyclic or aromatic group and R2 is a lower alkyl group by treating a glycidic acid ester derivative having the formul

Butenoic and pyruvic acid derivatives

Process for preparing a 2-hydroxy-butenoic acid derivative of the general formula, STR1 wherein R1 is a group selected from aliphatic, alicyclic or aromatic radicals and R2 is a lower alkyl group by heating a glycidic acid derivative

2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for the production thereof

A new process for the production of a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 2-hydroxy-3-(4-alkylphenyl)-3-butenoate, a new compound, with an alkali metal alcoholate in an alcohol to give the corresponding alkyl 3-methyl-3-(4-alkylphenyl)-pyruvate, also a new compound, which is then hydrolysed to liberate the corresponding 3-methyl-3-(4-alkylphenyl)-pyruvic acid, and then oxidising the liberated pyruvic acid compound to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way with a high yield of the desired product and is much suitable for a commercial practice than the prior art methods.

Process of producing a 2-(4-alkylphenyl)-propionic acid

A new process of producing a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 3-methyl-3-(4-alkylphenyl)-glycidate with an acid to produce 2-(4-alkylphenyl)-propionaldehyde and 3-methyl-3-(4-alkylphenyl)-pyruvic acid through a new reaction, and then oxidising these intermediate products to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way, gives a high yield of the desired product and is suitable for a commercial practice.