54017-13-9Relevant academic research and scientific papers
Butenoic and pyruvic acid derivatives
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, (2008/06/13)
Process for preparing a 2-hydroxy-butenoic acid derivative of the general formula, STR1 wherein R1 is a group selected from aliphatic, alicyclic or aromatic radicals and R2 is a lower alkyl group by heating a glycidic acid derivative
Process for producing 2-hydroxy-3-butenoic acid derivatives
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, (2008/06/13)
Process for producing a 2-hydroxy-3-butenoic acid derivative having the formula STR1 wherein R1 is an aliphatic, alicyclic or aromatic group and R2 is a lower alkyl group by treating a glycidic acid ester derivative having the formul
2-Hydroxy-3(4-alkylphenyl)-3-butenoic acid ester and process for the production thereof
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, (2008/06/13)
A new process for the production of a 2-(4-alkylphenyl)-propionic acid known as a valuable anti-inflammatory agent is now provided, which comprises treating an alkyl 2-hydroxy-3-(4-alkylphenyl)-3-butenoate, a new compound, with an alkali metal alcoholate in an alcohol to give the corresponding alkyl 3-methyl-3-(4-alkylphenyl)-pyruvate, also a new compound, which is then hydrolysed to liberate the corresponding 3-methyl-3-(4-alkylphenyl)-pyruvic acid, and then oxidising the liberated pyruvic acid compound to the desired 2-(4-alkylphenyl)-propionic acid. This new process is operable in a facile way with a high yield of the desired product and is much suitable for a commercial practice than the prior art methods.
