53607-41-3

Basic information

• Product Name: phenyl 2-nitropropanoate
• Synonyms: phenyl 2-nitropropanoate
• CAS NO: 53607-41-3
• Molecular Weight: 195.175
• Mol File: 53607-41-3.mol

Chemical Properties

• CAS DataBase Reference: phenyl 2-nitropropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: phenyl 2-nitropropanoate(53607-41-3)
• EPA Substance Registry System: phenyl 2-nitropropanoate(53607-41-3)

Safety Data

• Hazardous Substances Data: 53607-41-3(Hazardous Substances Data)

Upstream product

• 42710-26-9 phenyl 2-bromopropionate 

Relevant articles and documents

Enantioselective Addition of α-Nitroesters to Alkynes

By using Rh–H catalysis, we couple α-nitroesters and alkynes to prepare α-amino-acid precursors. This atom-economical strategy generates two contiguous stereocenters, with high enantio- and diastereocontrol. In this transformation, the alkyne undergoes isomerization to generate a RhIII–π-allyl electrophile, which is trapped by an α-nitroester nucleophile. A subsequent reduction with In powder transforms the allylic α-nitroesters to the corresponding α,α-disubstituted α-amino esters.