42710-26-9

Usage

Uses

Used in Pharmaceutical Synthesis:
Phenyl 2-bromopropanoate is utilized as a key intermediate in the production of various pharmaceuticals. Its unique structure allows for the creation of a range of medicinal compounds, contributing to the development of new drugs and therapies.
Used in Organic Chemical Synthesis:
As a reagent in organic synthesis, phenyl 2-bromopropanoate is employed for the preparation of a variety of organic compounds. Its reactivity and functional groups make it suitable for multiple types of chemical reactions, facilitating the synthesis of complex organic molecules.
Used in Research and Development:
In the field of research and development, phenyl 2-bromopropanoate serves as a valuable tool for exploring new chemical reactions and pathways. Its use in academic and industrial laboratories aids in the discovery of novel chemical processes and the advancement of synthetic methodologies.

Upstream product

• 139-02-6 sodium phenoxide 
• 71-43-2 benzene 
• 563-76-8 α-bromopropionyl bromide 
• 108-95-2 phenol 
• 7148-74-5 2-Bromopropionyl chloride 
• 598-72-1 2-Bromopropionic acid 
• 164594-13-2 Phenyl[2-(trimethylsilyl)phenyl]iodonium trifluoromethanesulfonate 

Downstream Products

• 116435-79-1 2-phenoxy-propionic acid phenyl ester 
• 57927-12-5 2-methyl-benzofuran-3-ol 
• 53607-41-3 phenyl 2-nitropropanoate 
• 39489-70-8 2-(4-Chloro-phenoxy)-propionic acid phenyl ester 
• 52111-19-0 diethyl (1-carbamoylethyl)phosphonate 
• 126486-00-8 3-methyl-4,4-dipropyl-2-oxetanone 
• 74686-89-8 (+/-)-trans-4-tert-Butyl-3-methyloxetan-2-one 
• 126485-97-0 4,4-diethyl-3-methyl-2-oxetanone 
• 53946-87-5 2-bromo-(4'-hydroxyphenyl)-propan-1-one 
• 6968-35-0 7-hydroxy-indan-1-one 
• 3470-49-3 5-hydroxy-2,3-dihydro-1H-indene-1-one 
• 63923-67-1 2-bromo-1-(2-hydroxy-phenyl)-propan-1-one 

Relevant academic research and scientific papers

Cobalt-bisoxazoline-catalyzed asymmetric kumada cross-coupling of racemic α-bromo esters with aryl grignard reagents

The first cobalt-catalyzed asymmetric Kumada cross-coupling with high enantioselectivity has been developed. The reaction affords a unique strategy for the enantioselective arylation of α-bromo esters catalyzed by a cobalt-bisoxazoline complex. A variety of chiral α-arylalkanoic esters were prepared in excellent enantioselectivity and yield (up to 97% ee and 96% yield). The arylated products were transformed into α-arylcarboxylic acids and primary alcohols without erosion of ee. The new enantioenriched α-arylpropionic esters synthesized herein are potentially useful in the development of nonsteroidal anti-inflammatory drugs. This method was conducted on gram-scale and applied to the synthesis of highly enantioenriched (S)-fenoprofen and (S)-ar-turmerone.

Enantioselective carbenoid insertion into phenolic O-H bonds with a chiral copper(I) imidazoindolephosphine complex

The enantioselective O-H carbenoid insertion reaction with a new chiral copper(I) imidazoindolephosphine complex has been developed. The chiral copper(I) complex catalyzed the insertion of carbenoids derived from α-diazopropionates into the O-H bonds of various phenol derivatives to give the corresponding α-aryloxypropionates with up to 91% ee.

O-arylation of carboxylic acids using (phenyl)[2-(trimethylsilyl)phenyl] iodonium triflate as a precursor of arynes

Using (phenyl)[2-(trimethylsilyl)phenyl]iodonium triflate as a precursor of arynes, Larock's method for O-arylation of carboxylic acids and arynes was developed. A variety of acids including simple aliphatic carboxylic acids, aromatic carboxylic acids, allenoic acids, and p-toluenesulfonic acid under mild reaction conditions could generate the aryl esters. Copyright Taylor & Francis Group, LLC.

Efficient radical oxygenation of α-lodocarboxylic acid derivatives

(equation presented) Treatment of α-iodocarboxylic acid derivatives with 2 equiv of triethylborane under oxygen atmosphere gives the corresponding α-hydroxy add derivatives This method is based on an iodine atom transfer from the ethyl radical, generated by the reaction of riethylborane and oxygen, with the α-iodocarbonyl compound. It offers several advantages over classical ionic substitution reactions: no elimanation product is observed tertiary iodides are efficiently converted to alcohos, and finally, this one-step procedure is working with substrates sensitive to nucleophiles.

Synthesis of substituted β-lactones by a Reformatsky reaction of carbonyl compounds, phenyl α-bromoalkanoates, and indium

Di-, tri-, and tetrasubstituted β-lactones are accessible in a one-step procedure by a Reformatsky reaction of phenyl α-bromoalkanoates with ketones or aldehydes at a sacrificial indium anode. With indium powder comparable results are obtained. The yield of β-lactones is significantly lower, if zinc is used instead of indium.