5361-37-5Relevant academic research and scientific papers
Quinazolines as adenosine receptor antagonists: SAR and selectivity for A2B receptors
Webb, Thomas R.,Lvovskiy, Dmitriy,Kim, Soon-Ai,Ji, Xiao-Duo,Melman, Neli,Linden, Joel,Jacobson, Kenneth A.
, p. 77 - 85 (2007/10/03)
We have recently reported the discovery of numerous new compounds that are selective inhibitors of all of the subtypes of the adenosine receptor family via a pharmacophore database searching and screening strategy. During the course of this work we made the unexpected discovery of a potent A2B receptor antagonist, 4-methyl-7-methoxyquinazolyl-2-(2′-amino-4′-imidazolinone) (38, CMB 6446), which showed selectivity for this receptor and functioned as an antagonist, with a binding Ki value of 112 nM. We explored the effects of both substituent- and ring-structural variations on the receptor affinity in this series of derivatives, which were found to be mostly non-selective adenosine receptor ligands with Ki values in the micromolar range. Since no enhancement of A2B receptor affinity of 38 was achieved, the previously reported pharmacophore-based searching strategy yielded the most potent and selective structurally-related hit in the database originally searched.
