53616-16-3

Basic information

• Product Name: N-(o-Chlorophenyl)maleamidic acid
• Synonyms: N-(o-Chlorophenyl)maleamidic acid;(Z)-4-((2-chlorophenyl)amino)-4-oxobut-2-enoic acid;(2Z)-3-[(2-chlorophenyl)carbamoyl]prop-2-enoic acid
• CAS NO: 53616-16-3
• Molecular Formula: C₁₀H₈ClNO₃
• Molecular Weight: 225.63
• Mol File: 53616-16-3.mol
• Article Data: 8

Chemical Properties

• Melting Point: 132 °C
• Boiling Point: 459.8°Cat760mmHg
• Flash Point: 231.9°C
• Appearance: /
• Density: 1.448g/cm³
• Vapor Pressure: 3E-09mmHg at 25°C
• Refractive Index: 1.642
• PKA: 2.69±0.25(Predicted)
• CAS DataBase Reference: N-(o-Chlorophenyl)maleamidic acid(CAS DataBase Reference)
• NIST Chemistry Reference: N-(o-Chlorophenyl)maleamidic acid(53616-16-3)
• EPA Substance Registry System: N-(o-Chlorophenyl)maleamidic acid(53616-16-3)

Safety Data

• Hazardous Substances Data: 53616-16-3(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8ClNO3/c11-7-3-1-2-4-8(7)12-9(13)5-6-10(14)15/h1-6H,(H,12,13)(H,14,15)/b6-5-

Upstream product

• 108-31-6 maleic anhydride 
• 95-51-2 o-chloroaniline 
• 91360-26-8 N-(2-furylmethylene)-o-chloraniline 

Downstream Products

• 1203-24-3 N-(2-chlorophenyl)maleimide 
• 80167-52-8 (Z)-3-methoxycarbonyl-N-(o-chlorophenyl)propenamide 
• 80167-60-8 (E)-3-methoxycarbonyl-N-(o-chlorophenyl)propenamide 
• 106691-39-8 (3-oxo-3,4-dihydro-2H-benzo[1,4]thiazin-2-yl)-acetic acid-(2-chloro-anilide) 
• 105703-67-1 N,N-dimethylamide-2'-chlorofumaranilide 
• 120564-83-2 N,N-dimethylamide-2'-chloromaleanilide 
• 71782-74-6 5-(2-chlorophenylimino)-2(5H)-furanone 
• 54012-44-1 N-(2-chloro-phenyl)-2-[3-(4-methyl-anilino)-4-oxo-2-thioxo-thiazolidin-5-yl]-acetamide 
• 54012-39-4 2-(3-anilino-4-oxo-2-thioxo-thiazolidin-5-yl)-N-(2-chloro-phenyl)-acetamide 
• 120564-85-4 (Z)-But-2-enedioic acid (2-chloro-phenyl)-(2-cyano-ethyl)-amide dimethylamide 
• 120564-84-3 (Z)-But-2-enedioic acid (2-chloro-phenyl)-methyl-amide dimethylamide 
• 104086-51-3 N-(2-cyanoethyl)-N',N'-dimethyl-2'-chlorofumaranilide 
• 105703-68-2 N,N',N'-trimethyl-2'-chlorofumaranilide 
• 105703-62-6 N,N-dimethyl-2'-ethylfumaranilide 

Relevant articles and documents

Curcumin-inspired cytotoxic 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones: A novel group of topoisomerase II alpha inhibitors

Three series of novel 3,5-bis(arylmethylene)-1-(N-(ortho-substituted aryl)maleamoyl)-4-piperidones, designed as simplified analogs of curcumin with maleic diamide tether, were synthesized and bioevaluated. These compounds displayed potent cytotoxicity tow

Synthesis and antifungal activity of N-(alkyl/aryl)-2-(3-oxo-1,4- benzothiazin-2-yl)acetamide

A series of N-(alkyl/aryl)-2-(3-oxo-1,4-benzothiazin-2-yl)acetamide have been synthesized by condensation of substituted amines with maleic anhydride (MA) followed by cyclization with o-aminothiophenol (o-ATP). All the compounds have been screened for their antifungal activity against Tricophyton rubrum, Epidermophyton floccosum and Malassazia furfur. In the primary screening, some of the compounds exhibited appreciable activity. The structures of the synthesized compounds 7a-z have been established on the basis of elemental analysis and spectral data.

Synthesis and Isomerization of the N,N-Dimethylamides of the 2'-Chloromaleanilic Acids.

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