104086-51-3Relevant academic research and scientific papers
Diastereotopic Effect of the Methylene Protons in N-ortho-Substituted-N-β-cyanoethylanilides: X-Ray Structure of N-(β-Cyanoethyl)-2'-chloromaleanilic Acid
Rodriguez, J. Gonzalez,Canoira, Laureano,Calderon, C. Esteban,Martinez-Ripoll, M.,Blanco, S. Garcia
, p. 199 - 204 (2007/10/02)
Some N-β-cyanoethyl-ortho-substituted anilides show a diastereotopic coupling effect of the methylene protons of the N-β-cyanoethyl chain in the 1H n.m.r. spectra.Resolution of those proton coupling systems have been done by computational methods and thei
Synthesis of Oxindole Derivatives from N-Alkenyl-o-Chloroanilides with Zero-Valent Nickel Complex
Canoira, L.,Rodriguez, J. G.
, p. 1511 - 1518 (2007/10/02)
Oxindole derivatives have been obtained from N-alkenyl-o-chloroanilides by reaction with tetrakis(triphenylphoaphine)nickel(0) in toluene as solvent in good yields.A detailed analysis of all the products of the reaction allows to confirm the postulated mechanism of the cyclization reaction.The o-chloroanilides of the 3-cyclohexenylacetic acid fails in the cyclization reaction, since the torsional hindrance seems to avoid that the endocyclic double bond may be orthogonally to the ortho-?-nickel complex intermediate on the aromatic ring.
