5362-72-1Relevant academic research and scientific papers
Copper-catalyzed direct ortho-alkylation of N-iminopyridinium ylides with N-tosylhydrazones
Xiao, Qing,Ling, Lin,Ye, Fei,Tan, Renchang,Tian, Leiming,Zhang, Yan,Li, Yuxue,Wang, Jianbo
supporting information, p. 3879 - 3885 (2013/05/22)
Copper-catalyzed cross-coupling of N-tosylhydrazones with N-iminopyridinium ylides leads to the direct C-H alkylation. This direct C-H bond alkylation transformation uses inexpensive CuI as the catalyst without any ligand. The reaction is operationally simple and conducted under mild conditions, giving the corresponding alkylated pyridines in moderate to good yields. DFT calculation provides insights into the reaction mechanism, suggesting that the reaction proceeds through the Cu carbene migratory insertion process.
Pd-catalyzed C=C double-bond formation by coupling of N-tosylhydrazones with benzyl halides
Xiao, Qing,Ma, Jian,Yang, Yang,Zhang, Yan,Wang, Jianbo
supporting information; scheme or table, p. 4732 - 4735 (2009/12/24)
Pd-catalyzed reaction of N-tosylhydrazones with benzyl halides affords di- and trisubstituted olefins In high yields with excellent stereoselectivity. This coupling reaction Is supposed to proceed through a migratory insertion of Pd carbene species.
