53627-32-0Relevant academic research and scientific papers
Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN3Pincer Catalyst
Hofmann, Natalie,Homberg, Leonard,Hultzsch, Kai C.
supporting information, p. 7964 - 7970 (2020/11/02)
A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN3 pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.
Thiourea as an efficient organocatalyst for the transfer hydrogenation of 2-substituted quinoline derivatives
Qiao, Xiang,Zhang, Zhiguo,Bao, Zongbi,Su, Baogen,Xing, Huabin,Yang, Qiwei,Ren, Qilong
, p. 42566 - 42568 (2015/02/19)
This study reports on the first transfer hydrogenation of 2-substituted quinolines promoted by a thiourea catalyst with Hantzsch ester as the hydrogen source. A wide range of quinoline derivatives, including 2-alkylquinolines and 2-arylquinolines, were ef
The remarkable effect of a simple ion: Iodide-promoted transfer hydrogenation of heteroaromatics
Wu, Jianjun,Wang, Chao,Tang, Weijun,Pettman, Alan,Xiao, Jianliang
supporting information; experimental part, p. 9525 - 9529 (2012/08/28)
I can do it! Accelerated by simple iodide ions, rhodium-catalysed transfer hydrogenation can be readily performed on quinolines, isoquinolines and quinoxalines, affording the tetrahydro products in high yields with low catalyst loading (see scheme). Copyright
4- [HETEROCYCLYL-METHYL] -8-FLUORO-QUINOLIN-2-ONES USEFUL AS NITRIC OXIDE SYNTHASE INHIBITORS
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Page/Page column 58-59, (2009/04/25)
Novel compounds of formulae (II, III) and pharmaceutical compositions have been found to inhibit inducible NOS synthase wherein: R4, R5, R6 and R7 are independently selected from the group consisting of hydrogen, lower alkyl, and halogen; and, R8 has the structure whrein X1, X2, X3, X4, X5, X6, R9, R13, R14 and n are as described herein.
Metal-free Br?nsted acid catalyzed transfer hydrogenation - New organocatalytic reduction of quinolines
Rueping, Magnus,Theissmann, Thomas,Antonchick, Andrey P.
, p. 1071 - 1074 (2007/10/03)
The first metal-free Br?nsted acid catalyzed hydrogenation of quinolines using Hantzsch dihydropyridine as the hydrogen source has been developed. This, so far unprecedented organocatalytic reduction of heteroaromatic compounds provides a variety of differently substituted 1,2,3,4-tetrahydroquinolines in excellent yields under mild reaction conditions using a remarkably low amount of Br?nsted acid catalyst. Georg Thieme Verlag Stuttgart.
Switching Androgen Receptor Antagonists to Agonists by Modifying C-Ring Substituents on Piperidinoquinolinone
Zhi, Lin,Tegley, Christopher M.,Marschke, Keith B.,Jones, Todd K.
, p. 1008 - 1012 (2007/10/03)
New nonsteroidal human androgen receptor (hAR) agonists were developed from an hAR antagonist pharmacophore, 2(1H-piperidinoquinolinone. (+/-)-trans-7,8-diethyl-4-trifluoromethyl-2(1H)-piperidinoquinolinone was synthesized and demonstrated p
