17507-24-3Relevant academic research and scientific papers
Synthesis of Tetrahydroquinolines via Borrowing Hydrogen Methodology Using a Manganese PN3Pincer Catalyst
Hofmann, Natalie,Homberg, Leonard,Hultzsch, Kai C.
supporting information, p. 7964 - 7970 (2020/11/02)
A straightforward and selective synthesis of 1,2,3,4-tetrahydroquinolines starting from 2-aminobenzyl alcohols and simple secondary alcohols is reported. This one-pot cascade reaction is based on the borrowing hydrogen methodology promoted by a manganese(I) PN3 pincer complex. The reaction selectively leads to 1,2,3,4-tetrahydroquinolines thanks to a targeted choice of base. This strategy provides an atom-efficient pathway with water as the only byproduct. In addition, no further reducing agents are required.
Bio-mediated oxidative resolution of racemic 2-substituted 1,2,3,4-tetrahydroquinolines
Qin, Lei,Zheng, Daijun,Cui, Baodong,Wan, Nanwei,Zhou, Xiaojian,Chen, Yongzheng
supporting information, p. 2403 - 2405 (2016/05/19)
Whole cell of Pseudomonas monteilii ZMU-T01 strains mediated oxidative resolution of racemic 2-substituted 1,2,3,4-tetrahydroquinolines has been successfully described. A series of highly enantioselective 2-substituted 1,2,3,4-tetrahydroquinoline derivatives were obtained in up to 50% conversion and >99% ee.
Photoaddition of Olefins to Quinolin-, Isoquinolin- and Phthalazin-thione Systems
Sato, Eisuke,Ikeda, Yoshiya,Kanaoka, Yuichi
, p. 273 - 276 (2007/10/02)
Irradiation of quinolin-2-, isoquinolin-1-, and phthalazin-1-thiones with olefins afforded photoaddition products: substituted quinolines, isoquinolines and phthalazines at the thiocarbonyl carbon.A new addition-cyclization was found producing tricyclic thiopyrano-isoquinolines and -phthalazines.
