53628-47-0

Upstream product

• 53628-42-5 (4-methoxy-benzylidene)-[2-(4-methoxy-phenyl)-4-phenyl-thiazol-5-yl]-amine 
• 884860-70-2 2,2,2-trifluoro-N-[2-(4-methoxy-phenyl)-4-phenyl-thiazol-5-yl]-acetamide 
• 1061709-63-4 [2-(4-methoxyphenyl)-4-phenylthiazol-5-yl]-(1,1,3,3-tetramethylbutyl)amine 
• 16750-42-8 2-amino-2-phenylacetonitrile 
• 100-07-2 4-methoxy-benzoyl chloride 
• 884860-65-5 N-(carbamoyl-phenyl-methyl)-4-methoxy-benzamide 
• 700-63-0 (R)-phenylglycine amide 

Downstream Products

• 1187843-63-5 N-(2-(4-methoxyphenyl)-4-phenylthiazol-5-yl)benzo[d]thiazole-2-carboxamide 
• 1187843-65-7 4-chloro-N-(2-(4-methoxyphenyl)-4-phenylthiazol-5-yl)benzamide 
• 1187843-64-6 4-methoxy-N-(2-(4-methoxyphenyl)-4-phenylthiazol-5-yl)benzamide 

Relevant academic research and scientific papers

Versatile assembly of 5-aminothiazoles based on the Ugi four-component coupling

A flexible route to novel 5-aminothiazoles has been developed based on cyclisation of diamide adducts, prepared using the Ugi reaction, in the presence of Lawesson's reagent. The Walborsky reagent (1,1,3,3-tetramethylbutyl isocyanide) was used as the isonitrile component, facilitating subsequent deprotection of the N-alkyl group to yield free 5-aminothiazoles, which were prepared with a variety of substituents at the 2- and 4-positions.

Synthesis of 5-aminothiazoles as building blocks for library synthesis

A convenient route to 4-phenyl-5-aminothiazoles is described, which offers control over substitution at the 2-position. 2-N-Acylglycinamides were dithionated and a subsequent TFAA-mediated cyclisation step was followed by removal of the 5-N-trifluoroacety