53638-84-9

Upstream product

• 95406-19-2 3-Chloromethyl-2-[2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid methyl ester 
• 3595-22-0 methyl(6R,7R)-3-acetoxymethyl-7-phenylacetamidoceph-3-em-4-carboxylate 
• 82895-15-6 (R)-3-Chloromethyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid methyl ester 
• 82895-09-8 (R)-3-Methyl-2-[(2R,3R)-2-(4-nitro-benzenesulfonylsulfanyl)-4-oxo-3-phenylacetylamino-azetidin-1-yl]-but-3-enoic acid methyl ester 
• 82895-10-1 (R)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-methyl-but-3-enoic acid methyl ester 
• 82895-16-7 (R)-2-((2R,3R)-2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid methyl ester 
• 93921-10-9 methyl 2-[3-phenylacetamido-4-(p-nitrobenzenesulfonylthio)-2-azetidinone-1-yl]-3-methyl-3-butenoate 
• 93861-45-1 2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-methyl-but-3-enoic acid methyl ester 
• 95406-16-9 2-(2-Benzenesulfonylsulfanyl-4-oxo-3-phenylacetylamino-azetidin-1-yl)-3-chloromethyl-but-3-enoic acid methyl ester 

Relevant academic research and scientific papers

PENICILLIN-CEPHALOSPORIN CONVERSION III. A NOVEL ROUTE TO 3-CHLOROMETHYL-Δ3-CEPHEMS

Synthesis of 3-chloromethyl-Δ3-cephems 3 from 4-arenesulfonylthioazetidin-2-ones 1, derived from penicillins G and V, has been achived by the electrolytic ene-type chlorination of 1 in a CHCl3-aqueous NaCl-H2SO4-(Pt electrodes) system and subse