53639-70-6Relevant articles and documents
Preparation method of 25-hydroxyl-7-dehydrocholesterol
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Paragraph 0015; 0017, (2017/08/31)
The invention discloses a preparation method of 25-hydroxyl-7-dehydrocholesterol. The preparation method takes 5,7,24-trienecholesterol as a raw material; 3-site hydroxyl of the raw material is protected to prepare an intermediate compound II; the intermediate compound is subjected to D-A protection reaction of diene to obtain an intermediate compound III; the intermediate compound III is subjected to double-bond halogenation and hydroxylation reaction to obtain an intermediate compound IV; the intermediate compound IV is subjected to de-protection and debromination reaction to prepare the 25-hydroxyl-7-dehydrocholesterol. By adopting the method provided by the invention, the 25-hydroxyl-7-dehydrocholesterol is obtained; compared with a preparation method reported in existing literature reports, the product yield is high and the purity is good; the reaction selectivity is relatively good and reaction operation is simple; pollution caused by a mercury-containing toxic and harmful reagent is effectively avoided; the cost of three wastes is reduced and the preparation method is suitable for industrialized popularization and application.
