5365-23-1

Basic information

• Product Name: (2,2-DICHLOROCYCLOPROPYL)METHANOL
• Synonyms: (2,2-DICHLOROCYCLOPROPYL)METHANOL;1,1-Dichloro-2-(hydroxymethyl)cyclopropane;2,2-Dichloro-1-(hydroxymethyl)cyclopropane;2,2-Dichlorocyclopropanemethanol
• CAS NO: 5365-23-1
• Molecular Formula: C₄H₆Cl₂O
• Molecular Weight: 141
• Mol File: 5365-23-1.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 82-85℃
• Flash Point: 98 °C
• Appearance: White solide
• Density: 1.44 g/cm³
• Refractive Index: 1.4870 (20℃)
• PKA: 15.10±0.10(Predicted)
• CAS DataBase Reference: (2,2-DICHLOROCYCLOPROPYL)METHANOL(CAS DataBase Reference)
• NIST Chemistry Reference: (2,2-DICHLOROCYCLOPROPYL)METHANOL(5365-23-1)
• EPA Substance Registry System: (2,2-DICHLOROCYCLOPROPYL)METHANOL(5365-23-1)

Safety Data

• Hazard Codes: Xi
• HazardClass: IRRITANT
• Hazardous Substances Data: 5365-23-1(Hazardous Substances Data)

Usage

General Description

(2,2-Dichlorocyclopropyl)methanol, also known as DCPM, is a chemical compound with the formula C4H6Cl2O. It is a cyclopropane derivative that is used as a building block in organic synthesis and as a reagent in medicinal chemistry. DCPM has been studied for its potential use in pharmaceutical applications, particularly as an intermediate in the synthesis of various drugs. It is a colorless liquid with a chloroform-like odor, and it is classified as a hazardous chemical due to its potential acute toxicity and environmental hazards. Overall, DCPM is an important compound for the development of new chemical and pharmaceutical products.

Upstream product

• 5365-14-0 2,2-dichlorocyclopropanecarboxylic acid 
• 119060-47-8 tert-Butyl 2,2-dichlorocyclopropanecarboxylate 
• 72733-56-3 propionic acid 2,2-dichlorocyclopropylmethane ester 
• 64794-14-5 1,1-bis<(2,2-dichlorocyclopropyl)methoxy>ethane 
• 64794-13-4 Acetaldehyd-2,2-dichlorcyclopropylmethyl-ethylacetal 
• 22084-97-5 1,1-Dichlor-2-trimethylsiloxymethyl-cyclopropan 

Downstream Products

• 89723-51-3 trans-(2-Chlorocyclopropyl)carbinol 
• 316377-54-5 (+)-(S)-2,2-dichlorocyclopropanemethanol 
• 6061-06-9 1,1-dichlorobuta-1,3-diene 
• 89723-51-3 cis-(2-Chlorocyclopropyl)carbinol 
• 89723-51-3 (2-Chlorocyclopropyl)carbinol 
• 5365-14-0 2,2-dichlorocyclopropanecarboxylic acid 

Relevant articles and documents

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ARYL, HETEROARY, AND HETEROCYCLIC PHARMACEUTICAL COMPOUNDS FOR TREATMENT OF MEDICAL DISORDERS

Complement Factor D inhibitors, pharmaceutical compositions, and uses thereof, as well as processes for their manufacture are provided. The compounds provided include Formula I, Formula II, Formula III, Formula IV, and Formula V, or a pharmaceutically acceptable salt, prodrug, isotopic analog, N-oxide, or isolated isomer thereof, optionally in a pharmaceutically acceptable composition. The inhibitors described herein target Factor D and inhibit or regulate the complement cascade.

Reduction of Cyclopropanecarboxylic Acids by Borane, a Chemoselective Reaction Sensitive to Steric Interactions and Reaction Conditions

A number of cyclopropanecarboxylic acids have been reduced by borane in tetrahydrofuran to the corresponding cyclopropyl alcohols. The yield was sensitive to the steric influence of the substituents attached to the ring, the reaction temperature, and the