5365-80-0Relevant academic research and scientific papers
Selective Debromination of α,α,α-Tribromomethylketones with HBr–H2O Reductive Catalytic System
Cheng, Zhao,Guo, Hongmei,Huang, Guozheng,Rexit, Abulikemu Abudu,Wang, Hui,Zheng, Meng-Xia
, p. 6455 - 6458 (2020/10/21)
A debromination of α,α,α-tribromomethylketones is developed for chemoselective synthesis of α-mono- and α,α-dibromomethylketones with high selectivity under H2O–HBr reductive conditions. This method offers an efficient and direct way to synthesize α-mono or α,α-dibromomethylketone compounds in high to excellent yields through the process of HBr self-circulation in water.
Facile and efficient preparation of α-halomethyl ketones from α-diazo ketones catalyzed by iron(III) halides and silica gel
Shi, Xinxia,Zhang, Lingqiong,Yang, Pengfei,Sun, Han,Zhang, Yilan,Xie, Chunsong,Ou-yang, Zhen,Wang, Min
supporting information, p. 1200 - 1203 (2018/03/08)
An efficient and mild method for the synthesis of α-halomethyl ketones from α-diazo ketones was developed using ferric chloride or bromide as the halogen source and silica gel as the hydrogen source, with good to excellent yields.
Synthesis and antibiofilm activity of a second-generation reverse-amide oroidin library: A structure-activity relationship study
Eric Ballard,Richards, Justin J.,Wolfe, Amanda L.,Melander, Christian
experimental part, p. 10745 - 10761 (2009/12/04)
A second-generation library of 2-aminoimidazole-based derivatives incorporating a "reversed amide" (RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii. Most notably, an in-depth activity profile is reported for the most active subclass of derivatives that bear linear aliphatic chains off the amide bond. Additionally, further structural modifications of the core template, such as removal of the amide bond or substitution with a triazole isostere, resulted in the discovery of analogues with antibiofilm activities that varied with respect to their inhibition and dispersal properties of P. aeruginosa and A. baumannii biofilms.
Acylcarnitine analogues as topical, microbicidal spermicides.
Savle, Prashant S.,Doncel, Gustavo F.,Bryant, Stephen D.,Hubieki, M. Patricia,Robinette, R. Graham,Gandour, Richard D.
, p. 2545 - 2548 (2007/10/03)
Acylcarnitine analogues, (+)-6-Carboxylatomethyl-2-alkyl-4,4-dimethylmorpholinium (Z-n, where n = the number of carbons in the alkyl chain), synthesized in multi-gram quantities show in vitro activities as spermicides, anti-HIV agents, and inhibitors of the growth of Candida albicans. Activity improves with increasing chain length. Compound Z-15 is a candidate for further study as a topical, microbicidal spermicide.
A NEW RING SYNTHESIS FOR 3- AND POLYSUBSTITUTED FURANS: DIRECTING EFFECTS OF A 3-(ARENESULFONYL) GROUP IN METALATION AND FRIEDEL-CRAFTS PROCESSES
McCombie, S. W.,Shankar, B. B.,Ganguly, A. K.
, p. 4123 - 4126 (2007/10/02)
Primary and secondary α-bromoketones react with the potassium salt (3) to afford 2--ketones.On treatment with LDA followed by p-TsOH, good yields of the corresponding 3- or 2,3-substituted-4-tosylfuran are obtained, fro
