53657-95-7Relevant academic research and scientific papers
COMPOUNDS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION OF ANTIBIOTICS
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Page/Page column 97; 99-102, (2021/06/26)
Compounds and methods for use to treat a bacterial infection caused by, for example, gram positive bacteria, gram negative bacteria, and/or mycobacteria are provided herein. Also provided herein are compounds and methods for use in potentiating the effect of an antibiotic in the treatment of a bacterial infection. Pharmaceutical compositions including the compounds as described herein are also provided.
AMIDINES AND AMIDINE ANALOGS FOR THE TREATMENT OF BACTERIAL INFECTIONS AND POTENTIATION ANTIBIOTICS
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Page/Page column 390; 392, (2020/01/08)
Compounds and methods for the treatment of a bacterial infection or the potentiation of an antibiotic in treating a bacterial infection are described herein.
Synthesis and antiprotozoal activities of dicationic bis(phenoxymethyl)benzenes, bis(phenoxymethyl)naphthalenes, and bis(benzyloxy)naphthalenes
Patrick, Donald A.,Bakunov, Stanislav A.,Bakunova, Svetlana M.,Suresh Kumar,Chen, Heidi,Jones, Susan Kilgore,Wenzler, Tanja,Barzcz, Todd,Werbovetz, Karl A.,Brun, Reto,Tidwell, Richard R.
experimental part, p. 3543 - 3551 (2009/12/04)
A series of 37 dicationically substituted bis(phenoxymethyl)benzene bis(phenoxymethyl)naphthalene, and bis(benzyloxy)naphthalene analogues of pentamidine was prepared and evaluated for antiprotozoal activities and cytotoxicity in in vitro. 1,3-Bis(4-amidinophenoxymethyl)benzene (1) was the most active against Trypanosoma brucei rhodesiense (IC50 = 2.1 nM). 1,3-Bis[4-(N-isopropylamidino)phenoxymethyl]benzene (2) was most active against Plasmodium falciparum (IC50 = 3.6 nM) and displayed a selectivity index more than 50 times greater than that of pentamidine. Several other compounds displayed lower antiplasmodial IC50 values and higher selectivity indices relative to pentamidine. 1,4-Bis(4-amidinophenoxymethyl)benzene (14) was the most active against Leishmania donovani (IC50 = 1.3 μM). Compound 2 displayed the greatest activity against T. b. rhodesiense in vivo, curing three of four infected mice dosed intraperitoneally at 5 mg/kg × 4 days.
Antiparasitic Agents: Part VI - Synthesis of 1,2-, 1,3,- and 1,4-Bis(4-substituted aryloxy)benzenes and their Biological Activities
Chauhan, P. M. S.,Niyer, R.,Bhakuni, D. S.,Shankhdhar, V.,Guru, P.Y.,Sen, A. B.
, p. 38 - 42 (2007/10/02)
Several 1,2-, 1,3-, 1,4-bis(4-amidinophenoxy)benzenes (8-10); 1,2-, 1,3-, 1,4-bis(4-amidinobenzyloxy)benzenes (14-16) and 1,2-, 1,3-, 1,4-bis(4-amidinophenoxymethyl)benzenes (26-28) and the corresponding amidoximes (17-19), (29-31) and 33 have been synthe
