5366-37-0

Basic information

• Product Name: 2-Pyridinol, 4-nitrobenzoate (ester)
• CAS NO: 5366-37-0
• Molecular Formula: C12H8N2O4
• Molecular Weight: 244.207
• Mol File: 5366-37-0.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 2-Pyridinol, 4-nitrobenzoate (ester)(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Pyridinol, 4-nitrobenzoate (ester)(5366-37-0)
• EPA Substance Registry System: 2-Pyridinol, 4-nitrobenzoate (ester)(5366-37-0)

Safety Data

• Hazardous Substances Data: 5366-37-0(Hazardous Substances Data)

Upstream product

• 142-08-5 2-hydroxypyridin 
• 122-04-3 4-nitro-benzoyl chloride 
• 62-23-7 4-nitro-benzoic acid 
• 142-08-5 2-Pyridone 

Downstream Products

• 20852-57-7 2-(p-Nitro-benzoyl)-fluoren 
• 1144-74-7 4-nitrobenzophenone 
• 1429-05-6 phenyl 4-nitrobenzoate 
• 5397-76-2 1-morpholin-4-yl-1-(4-nitro-phenyl)-methanone 
• 72141-41-4 (4-nitro-phenyl)-piperazin-1-yl-methanone 
• 349091-32-3 3-methylpiperidin-1-yl(4-nitrophenyl)methanone 
• 20857-92-5 N-(p-nitrobenzoyl)azacyclohexane 

Relevant articles and documents

Heterogeneous Suzuki-Miyaura coupling of heteroaryl ester: Via chemoselective C(acyl)-O bond activation

A site-selective supported palladium nanoparticle catalyzed Suzuki-Miyaura cross-coupling reaction with heteroaryl esters and arylboronic acids as coupling partners was developed. This methodology provides a heterogeneous catalytic route for aryl ketone formation via C(acyl)-O bond activation of esters by successful suppression of the undesired decarbonylation phenomenon. The catalyst can be reused and shows high activity after eight cycles. The XPS analysis of the catalyst before and after the reaction suggested that the reaction might be performed via a Pd0/PdII catalytic cycle that began with Pd0.

Comparison of aminolysis of 2-pyridyl and 4-pyridyl x-substituted benzoates in acetonitrile: Evidence for a concerted mechanism involving a cyclic transition state

A kinetic study on reactions of 2-pyridyl X-substituted benzoates (6a-i) with a series of cyclic secondary amines in MeCN is reported. The Hammett plot for the reaction of 6a-i with piperidine consists of two intersecting straight lines while the Yukawa-Tsuno plot exhibits an excellent linear correlation with ρX = 1.28 and r = 0.63, indicating that the nonlinear Hammett plot is not caused by a change in the rate-determining step but rather by resonance stabilization of substrates possessing an electron-donating group (EDG) in the benzoyl moiety. The Bronsted-type plots are linear with βnuc = 0.59 ± 0.02, which is typical of reactions reported to proceed through a concerted mechanism. A cyclic transition state (TS), which forces the reaction to proceed through a concerted mechanism, is proposed. The deuterium kinetic isotope effect of 1.3 ± 0.1 is consistent with the proposed mechanism. Analysis of activation parameters reveals that ΔH? increases linearly as the substituent X changes from an electron-withdrawing group (EWG) to an EDG, while TΔS ? remains nearly constant with a large negative value. The constant TΔS? value further supports the proposal that the reaction proceeds through a concerted mechanism with a cyclic TS.