53666-01-6

Upstream product

• 21715-90-2 N-hydroxy-5-norbornene-2,3-dicarboximide 
• 1149-26-4 (S)-N-(benzyloxycarbonyl)valine 
• 137283-63-7 Carbonic acid 3,5-dioxo-4-aza-tricyclo[5.2.1.0^2,6]dec-8-en-4-yl ester isopropenyl ester 
• 89028-39-7 N,N'-dinorborneno oxallate(DPO) 

Downstream Products

• 73809-01-5 Boc-GlyIleValGlu(OBut)Gln(Mbh)-OH 
• 14485-95-1 Z-IleValGlu(OBut)-OH 
• 77277-62-4 N-(benzyloxycarbonyl)-L-valyl-D-isoglutamine t-butyl ester 
• 112579-59-6 Z-Val-γAbu-OBzl 
• 2766-17-8 ethyl N-(benzyloxycarbonyl)-L-valylglycinate 
• 5868-49-5 Z-ValGlu(OBut)-OH 
• 57294-39-0 Z-Val-Gly-OBzl 

Relevant academic research and scientific papers

An improved method for the synthesis of active esters of N-protected amino acids and subsequent synthesis of dipeptides

4-Dimethylaminopyridine-catalyzed reaction of mixed carbonates 3 with N-protected amino acids 4 gave the corresponding active esters 5-9, from which dipeptides 11-18 were synthesized by aminolysis with amino acids 10.

A Convenient Synthesis of Peptide Using Oxallates

The equimolar reactions of N-protected amino acids , amino acids or amino acid esters with oxallates (1a-1e) having active ester groups in the presence of pyridine in acetonitrile afforded the corresponding dipeptides via active esters in good yields.