53668-35-2

Usage

Uses

Used in Pharmaceutical Industry:
4-AMINO-N-ISOPROPYLBENZENESULFONAMIDE is used as an intermediate in the synthesis of sulfadiazine, an antibiotic that is effective against a variety of bacterial infections. Its role in the production of this antibiotic is crucial for treating conditions caused by susceptible bacteria.
Used in Agrochemical Industry:
4-AMINO-N-ISOPROPYLBENZENESULFONAMIDE also serves as an intermediate in the synthesis of certain agrochemicals, contributing to the development of products that protect crops from diseases and pests, thereby ensuring agricultural productivity.
Used in Dye and Pigment Industry:
4-AMINO-N-ISOPROPYLBENZENESULFONAMIDE is utilized in the synthesis of dyes and pigments, playing a significant role in the coloration of various materials used in different industries such as textiles, plastics, and printing inks.
Overall, 4-AMINO-N-ISOPROPYLBENZENESULFONAMIDE's applications span across multiple industries, highlighting its importance and versatility in chemical synthesis and product development.

InChI:InChI=1/C9H14N2O2S/c1-7(2)11-14(12,13)9-5-3-8(10)4-6-9/h3-7,11H,10H2,1-2H3

Upstream product

• 91430-85-2 N-Isopropyl-p-acetamido-benzol-sulfonamid 
• 121-60-8 p-acetylaminobenzenesulfonyl chloride 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 
• 23530-48-5 N-isopropyl-4-nitrobenzenesulfonamide 

Downstream Products

• 1241891-98-4 4-(3-chloro-1,4-dioxo-1,4-dihydronaphthalen-2-ylamino)-N-isopropylbenzenesulfonamide 
• 1391609-03-2 2-(3-bromo-phenyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid isopropylamide 
• 1391609-02-1 4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid isopropylamide 

Relevant academic research and scientific papers

Effect of photodynamic antibacterial chemotherapy combined with antibiotics on Gram-positive and gram-negative bacteria

The well-known and rapidly growing phenomenon of bacterial resistance to antibiotics is caused by uncontrolled, excessive and inappropriate use of antibiotics. One of alternatives to antibiotics is Photodynamic Antibacterial Chemotherapy (PACT). In the present study, the effect of PACT using a photosensitizer Rose Bengal alone and in combination with antibiotics including methicillin and derivatives of sulfanilamide synthesized by us was tested against antibiotic-sensitive and antibiotic-resistant clinical isolates of Gram-positive S. aureus and Gram-negative P. aeruginosa. Antibiotic-sensitive and resistant strains of P. aeruginosa were eradicated by Rose Bengal under illumination and by sulfanilamide but were not inhibited by new sulfanilamide derivatives. No increase in sensitivity of P. aeruginosa cells to sulfanilamide was observed upon a combination of Rose Bengal and sulfanilamide under illumination. All tested S. aureus strains (MSSA and MRSA) were effectively inhibited by PACT. When treated with sub-MIC concentrations of Rose Bengal under illumination, the minimum inhibitory concentrations (MIC) of methicillin decreased significantly for MSSA and MRSA strains. In some cases, antibiotic sensitivity of resistant strains can be restored by combining antibiotics with PACT.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the significance given in claim 1, can be used as AMPK modulators for treating obesity, hyperglycemia or type 2 diabetes.

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.

NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.