23530-48-5

Usage

Uses

Used in Pharmaceutical Industry:
N-Isopropyl-4-nitro-benzenesulfonamide is used as an intermediate in the synthesis of pharmaceuticals for its antimicrobial properties. It plays a crucial role in the manufacturing of anti-infective and antibacterial drugs, contributing to the development of treatments for various infections.
Used in Dye Industry:
N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE is also utilized as an intermediate in the synthesis of dyes, contributing to the production of a wide range of colorants used in various applications, including textiles, plastics, and printing inks.
Used in Pesticide Industry:
N-Isopropyl-4-nitro-benzenesulfonamide is employed in the production of pesticides, serving as an essential component in the development of effective and targeted crop protection solutions. Its role in pesticide synthesis helps ensure the protection of agricultural produce from pests and diseases.

Upstream product

• 108-30-5 succinic acid anhydride 
• 75-30-9 2-iodo-propane 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 75-31-0 isopropylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 24265-53-0 N-(2,4-Dinitro-phenylsulfanyl)-N-isopropyl-4-nitro-benzenesulfonamide 
• 24265-56-3 N-Isopropyl-4-nitro-N-phenylsulfanyl-benzenesulfonamide 
• 53668-35-2 sulfanilic acid N-(1-methylethyl) amide 
• 863968-65-4 N-isopropyl-N-(1-methyl-1H-pyrrol-2-yl)-4-nitro-benzenesulfonamide 
• 863968-61-0 C₉H₁₁ClN₂O₄S 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 1391609-03-2 2-(3-bromo-phenyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid isopropylamide 
• 1391609-02-1 4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid isopropylamide 

Relevant academic research and scientific papers

Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement

A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.

Intramolecular NC rearrangements involving sulfonamide protecting groups

The reaction of amine derivatives orthogonally protected with an aryl sulfonamide and a carbamate, via a base-mediated nitrogen to carbon rearrangement is reported. This noteworthy isomerisation has implications for the use of sulfonamide protecting group

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

A compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the significance given in claim 1, can be used as AMPK modulators for treating obesity, hyperglycemia or type 2 diabetes.

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.

NOVEL M3 MUSCARINIC ACETYLCHOLINE RECEPTOR ANTAGONISTS

Muscarinic Acetylcholine receptor antagonists and methods of using them are provided.

The reversed Kenner linker: A new safety-catch linker for the preparation of N-alkyl sulfonamides

matrix presented A new strategy for the solid-phase synthesis of sulfonamides is described. The Kenner safety-catch strategy has been modified such that the carboxylic acid component remains attached to the solid support while the sulfonamide portion is released into solution. An initial demonstration of the scope of this strategy is presented, along with an analysis of the cleavage characteristics and extension to more elaborate products via Suzuki reaction and thiazolidinone synthesis.

Phosphonamidic-Sulfonic Mixed Anhydrides: Possible Initial Products in the Base-induced Rearrangement Reactions of N-Phosphinoyl-O-sulfonylhydroxylamines

In PriNH2-ButNH2 competition experiments the behaviour of the two phosphonamidic-sulfonic mixed anhydrides 2 and 7 resembles that of the corresponding hydroxylamine derivatives 1 and 6.