23530-48-5

Basic information

• Product Name: N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE
• Synonyms: N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE;4-nitro-N-propan-2-ylbenzenesulfonamide
• CAS NO: 23530-48-5
• Molecular Formula: C₉H₁₂N₂O₄S
• Molecular Weight: 244.26758
• Mol File: 23530-48-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 112-113 °C
• Boiling Point: 388.1±44.0 °C(Predicted)
• Appearance: /
• Density: 1.318±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 10.69±0.50(Predicted)
• CAS DataBase Reference: N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE(23530-48-5)
• EPA Substance Registry System: N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE(23530-48-5)

Safety Data

• Hazardous Substances Data: 23530-48-5(Hazardous Substances Data)

Usage

General Description

N-Isopropyl-4-nitro-benzenesulfonamide is a chemical compound with the molecular formula C9H12N2O4S. It is a derivative of sulfonamide, which is a class of organic compounds containing a sulfur atom bonded to a nitrogen atom with a double bond and two oxygen atoms attached to the sulfur. N-Isopropyl-4-nitro-benzenesulfonamide is commonly used as an intermediate in the synthesis of pharmaceuticals, dyes, and pesticides. It is a yellow crystalline solid with a melting point of 150-152°C and is sparingly soluble in water. N-ISOPROPYL-4-NITRO-BENZENESULFONAMIDE is also known for its antimicrobial properties and is used in the manufacturing of anti-infective and antibacterial drugs.

Upstream product

• 108-30-5 succinic acid anhydride 
• 75-30-9 2-iodo-propane 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 75-31-0 isopropylamine 
• 98-74-8 4-Nitrobenzenesulfonyl chloride 

Downstream Products

• 53668-35-2 sulfanilic acid N-(1-methylethyl) amide 
• 1391609-03-2 2-(3-bromo-phenyl)-4,4-dimethyl-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid isopropylamide 
• 1391609-02-1 4,4-dimethyl-2-(3-morpholin-4-yl-phenyl)-1,2,3,4-tetrahydro-quinoline-6-sulfonic acid isopropylamide 
• 863968-65-4 N-isopropyl-N-(1-methyl-1H-pyrrol-2-yl)-4-nitro-benzenesulfonamide 
• 863968-61-0 C₉H₁₁ClN₂O₄S 
• 24265-56-3 N-Isopropyl-4-nitro-N-phenylsulfanyl-benzenesulfonamide 
• 6325-93-5 p-nitrobenzenesulfonamide 
• 24265-53-0 N-(2,4-Dinitro-phenylsulfanyl)-N-isopropyl-4-nitro-benzenesulfonamide 

Relevant articles and documents

Metal-Free β-Amino Alcohol Synthesis: A Two-step Smiles Rearrangement

A novel method for the synthesis of β-amino alcohols has been demonstrated under mild reaction conditions with a broad scope via a two-step Smiles rearrangement. What is more, theoretical calculations have been performed to confirm the rationality of the mechanism. The method has been proved to be notably effective for N-arylated amino alcohols, which are difficult to synthesize by traditional methods.

NOVEL TETRAHYDROQUINOLINE DERIVATIVES

The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or ester thereof, wherein R1 to R8, A1 to A3 have the are as described herein and compositions including the compounds.

Synthesis and biological evaluation of naphthoquinone analogs as a novel class of proteasome inhibitors

Screening of the NCI Diversity Set-1 identified PI-083 (NSC-45382) a proteasome inhibitor selective for cancer over normal cells. Focused libraries of novel compounds based on PI-083 chloronaphthoquinone and sulfonamide moieties were synthesized to gain a better understanding of the structure-activity relationship responsible for chymotrypsin-like proteasome inhibitory activity. This led to the demonstration that the chloronaphthoquinone and the sulfonamide moieties are critical for inhibitory activity. The pyridyl group in PI-083 can be replaced with other heterocyclic groups without significant loss of activity. Molecular modeling studies were also performed to explore the detailed interactions of PI-083 and its derivatives with the β5 and β6 subunits of the 20S proteasome. The refined model showed an H-bond interaction between the Asp-114 and the sulfonamide moiety of the PI-083 in the β6 subunit.