536710-87-9Relevant academic research and scientific papers
Parallel synthesis of glycomimetic libraries: targeting a C-type lectin.
Schuster, Michael C,Mann, David A,Buchholz, Tonia J,Johnson, Kathryn M,Thomas, William D,Kiessling, Laura L
, p. 1407 - 1410 (2007/10/03)
We have developed methods for the parallel synthesis of two libraries of non-carbohydrate-based analogues of mannose on a solid support. The natural product shikimic acid was used as a key building block. The ability of the compounds to block the binding of the C-type lectin MBP-A to a mannosylated surface was assessed in a high-throughput assay. Ten library members with inhibitory activities equivalent to that of alpha-methyl mannopyranoside were identified. [reaction: see text]
