53693-74-6Relevant academic research and scientific papers
Facile direct synthesis of unsymmetrical ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines using DABAL-Me3
Kang, Soosung,Kim, Hee-Kwon
, p. 4036 - 4046 (2018/06/13)
A practical synthetic method for the direct synthesis of unsymmetrically substituted ureas from N-Alloc-, N-Cbz-, and N-Boc-protected amines is described. In this study, efficient direct conversion of the Alloc-, Cbz-, and Boc-carbamate compounds to ureas was achieved in the presence of DABAL-Me3, an air stable and easily handled reagent. Using this reaction method, both protected aromatic and aliphatic amines were successfully transformed into various trisubstituted and tetrasubstituted ureas with high yields without side product. Our findings offer promising guidelines for direct preparation of useful ureas from N-Alloc-, N-Cbz-, and N-Boc-carbamates.
Palladium-Catalyzed Ortho-Selective C-H Oxidative Carbonylation of N-Substituted Anilines with CO and Primary Amines for the Synthesis of o-Aminobenzamides
Zhang, Xiaopeng,Dong, Shuxiang,Niu, Xueli,Li, Zhengwei,Fan, Xuesen,Zhang, Guisheng
supporting information, p. 4634 - 4637 (2016/09/28)
An efficient, one-pot strategy with high selectivity and high atom economy for the synthesis of o-aminobenzamides has been developed via palladium-catalyzed ortho-selective C-H oxidative carbonylation of N-substituted anilines with CO and primary amines. A wide range of N-substituted anilines and primary amines can be tolerated in this transformation to afford the corresponding o-aminobenzamides in moderate to excellent yields under mild conditions.
Conversion of O-succinimidyl carbamates to N-(O-carbamoyl)-succinmonoamides and ureas: Effects of N-substituents and reaction conditions on the reaction pathway
Vasilevich, Natalya I.,Coy, David H.
, p. 6649 - 6652 (2007/10/03)
Whereas N-monoalkyl-O-succinimidyl carbamates reacted with primary and secondary amines to produce only ureas, N,N-dialkyl-O-succinimidyl carbamates reacted with primary and secondary amines to produce N-(O-carbamoyl)-succinmonoamides. N-Alkyl-N-aryl-O-su
Conversion of carbonimidodithioates into unsymmetrical Di- and Tri- substituted ureas including urea dipeptides
Anbazhagan, Mariappan,Deshmukh, Abdul Rakeeb A. S.,Rajappa, Srinivasachari
, p. 3609 - 3612 (2007/10/03)
Selective hydrolysis of carbonimidodithioates (3) leads to the thiocarbamates (4), which can be easily transformed to the unsymmetrical ureas (5) by treatmeat with the appropriate amines. This constitutes a synthesis of ureas without the use of phosgene o
