53695-49-1Relevant academic research and scientific papers
The organocatalytic enantiodivergent fluorination of β-ketodiaryl-phosphine oxides for the construction of carbon-fluorine quaternary stereocenters
Xie, Shaolei,He, Zhi-Juan,Zhang, Ling-Hui,Huang, Bo-Lun,Chen, Xiao-Wei,Zhan, Zong-Song,Zhang, Fu-Min
supporting information, p. 2069 - 2072 (2021/03/01)
Commercially available cinchona alkaloids that can catalyze the enantiodivergent fluorination of β-ketodiarylphosphine oxides were developed to construct carbon-fluorine quaternary stereocenters. This protocol features a wide scope of substrates and excellent enantioselectivities, and it is scalable.
Synthesis, Antimicrobial Activity and Molecular Docking Study of Novel α-(Diphenylphosphoryl)- and α-(Diphenylphosphorothioyl)cycloalkanone Oximes
Jebli, Nejib,Hamimed, Selma,Van Hecke, Kristof,Cavalier, Jean-Fran?ois,Touil, Soufiane
, (2020/07/13)
A series of novel α-(diphenylphosphoryl)- and α-(diphenylphosphorothioyl)cycloalkanone oximes have been synthesized in search for novel bioactive molecules. Their structures were characterized by various spectroscopic methods including IR, NMR (1H, 31P, 13C), mass spectrometry and single crystal X-ray diffraction. The newly synthesized phosphorus-containing oximes were screened for their in vitro antimicrobial activity against Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis), Gram-negative bacteria (Escherichia coli and Salmonella typhimurium) and fungal strains (Candida albicans and Candida glabrata). The biological assays showed that all the studied compounds exhibited high antibacterial and antifungal activities at only 0.1–2.1 μg/mL. In silico molecular docking studies in FabH enzyme active site were performed in order to predict the possible interaction modes and binding energies of the drug candidates at the molecular level.
Direct Regio- and Diastereoselective Diphosphonylation of Cyclic Enamines: One-Pot Synthesis of α,α'-Bis(diphenylphosphoryl)- and α,α'-Bis(diphenylphosphorothioyl)cycloalkanones
Jebli, Nejib,Debrouwer, Wouter,Berton, Jan K.E.T.,Van Hecke, Kristof,Stevens, Christian V.,Touil, Soufiane
supporting information, p. 1160 - 1164 (2017/06/13)
A straightforward regio- and diastereoselective process has been developed for the synthesis of unprecedented symmetrical trans -α,α'-bis(diphenylphosphoryl)- and α,α'-bis(diphenylphosphorothioyl)-cycloalkanones, through the reaction of cyclic enamines with excess P -chlorodiphenylphosphine in the presence of triethylamine, followed by oxidation or sulfurization and hydrolytic workup.
PHOSPHORYLATION OF 1-MORPHOLINOCYCLOHEXENE AND CYCLOPENTENE. CONVENIENT METHOD OF SYNTHESIS OF α-PHOSPHORYLATED DERIVATIVES OF CYCLOHEXANONE AND CYCLOPENTANONE
Tolmachev, A. A.,Kostyuk, A. N.,Morozova, L. N.,Lampeka, R. D.,Kozlov, E. S.,Pinchuk, A. M.
, p. 1475 - 1484 (2007/10/02)
It was shown that 1-morpholinocyclopentene and 1-morpholinocyclohexene are readily phosphorylated by phosphorus(III) halides in the presence of triethylamine.From the compounds obtained, α-phosphorylated cyclopentanones and cyclohexanones were synthesized
