536972-31-3Relevant articles and documents
Design, synthesis, and biological evaluation of monopyrrolinone-based HIV-1 protease inhibitors
Smith III, Amos B.,Cantin, Louis-David,Pasternak, Alexander,Guise-Zawacki, Lisa,Yao, Wenquin,Charnley, Adam K.,Barbosa, Joseph,Sprengeler, Paul A.,Hirschmann, Ralph,Munshi, Sanjeev,Olsen, David B.,Schleif, William A.,Kuo, Lawrence C.
, p. 1831 - 1844 (2007/10/03)
The design, synthesis, and biological evaluation of a series of HIV-1 protease inhibitors [(-)-6, (-)-7, (-)-23, (+)-24] based upon the 3,5,5-trisubstituted pyrrolin-4-one scaffold is described. Use of a monopyrrolinone scaffold leads to inhibitors with i