53699-69-7Relevant academic research and scientific papers
Synthesis and crystal structures of N-Aryl-N-methylaminocyclohexanols
Cresswell, Alexander J.,Davies, Stephen G.,Hewings, David S.,Kurosawa, Wataru,Lee, James A.,Morris, Melloney J.,Roberts, Paul M.,Thompson, Amber L.,Thomson, James E.
, p. 646 - 654 (2013)
N-Aryl-N-methylaminocyclohexanols 10-12 were synthesised and their crystal structures were studied by X-ray diffraction. Compound 10 crystallizes in the monoclinic space group Cc with cell parameters of a = 13.7366(2) A, b = 13.7234(2) A, c = 26.9057(5) A, β = 93.0900(5), V = 5064.70(14) A3 and Z = 16. Compound 11 crystallizes in the trigonal space group P 3 with cell parameters of a = b = 25.4429(4) A, c = 9.6417(2) A, V = 5405.27(16) A3 and Z = 18. Compound 12 crystallizes in the monoclinic space group P21/n with cell parameters of a = 9.9511(2) A, b = 11.5777(2) A, c = 20.5968(4) A, β = 95.5037(9), V = 2362.04(8) A3 and Z = 8. All three structures were characterised by arrays of hydrogen bonding interactions and these crystallographic studies revealed conformations of 10-12 which gave valuable information into the mechanism of the reaction during their formation. Graphical Abstract: Crystals of (RS,RS,RS)-3-[N-methyl-N-(4'-methoxyphenyl) amino]cyclohexane-1,2-diol, (RS,RS,RS)-3-(N-methyl-N-phenylamino)cyclohexane-1, 2-diol and (RS,RS,RS)-2-fluoro-6-(N-methyl-N-phenylamino)cyclohexan-1-ol were synthesised and their structures were studied by X-ray diffraction.[Figure not available: see fulltext.].
Method for preparing allylamine compounds
-
Paragraph 0040, (2018/06/15)
The invention discloses a method for preparing allylamine compounds. The allylamine compounds are synthesized by taking an ionic iron (III) complex which has a molecular formula of [(RNCH2CH2NR)CH][FeBr4] (R is tert-butyl) and contains 1,3-di-tert-butyl imidazoline cation as a catalyst, taking di-tert-butyl peroxide as an oxidant and carrying out oxidative coupling reaction on amine compounds andallyl hydrocarbon compounds. The method disclosed by the invention has wide application range, can be used for aromatic amine containing an electron-withdrawing group, is effective for aromatic aminecontaining an electron-donating group, and is a first case of preparing the allylamine compounds through the oxidative coupling reaction of the amine compounds and the allyl hydrocarbon compounds, which is realized by an iron-based catalyst.
Intermolecular hydroaminoalkylation of alkenes and dienes using a titanium mono(formamidinate) catalyst
D?rfler, Jaika,Preu?, Till,Brahms, Christian,Scheuer, Dennis,Doye, Sven
, p. 12149 - 12168 (2015/07/15)
An easily accessible formamidinate ligand-bearing titanium complex initially synthesized by Eisen et al. is used as catalyst for intermolecular hydroaminoalkylation reactions of unactivated, sterically demanding 1,1- and 1,2-disubstituted alkenes and styr
Catalytic C-H Amination with aromatic amines
Gephart III, Raymond T.,Huang, Daria L.,Aguila, Mae Joanne B.,Schmidt, Graham,Shahu, Andi,Warren, Timothy H.
supporting information; experimental part, p. 6488 - 6492 (2012/07/30)
Aniline joins the club: A β-diketiminato copper(I) catalyst enables C-H amination of anilines employing low catalyst loadings to preclude oxidation to the diazene ArNi-NAr (see scheme). Electron-poor anilines are particularly resistant towards diazene formation and participate in the amination of strong and unactivated C-H bonds. N-alkyl anilines also take part in C-H amination. Copyright
Transition Metal-Catalyzed C-H Amination Using Unactivated Amines
-
Page/Page column 3, (2011/09/20)
One aspect of the invention relates to a method of animation or amidation, comprising the step of combining a substrate, comprising a reactive C—H bond, and an amine or amide, comprising a reactive N—H bond, in the presence of an oxidizing agent and a metal-containing catalyst, thereby forming a product with a covalent bond between the carbon of the reactive C—H bond and the nitrogen of the reactive N—H bond.
Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds
-
Page column 17; 19; 22, (2008/06/13)
The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.
Transition metal-catalyzed process for addition of amines to carbon-carbon double bonds
-
, (2008/06/13)
The present invention is directed to a process for addition of amines to carbon-carbon double bonds in a substrate, comprising: reacting an amine with a compound containing at least one carbon-carbon double bond in the presence a transition metal catalyst under reaction conditions effective to form a product having a covalent bond between the amine and a carbon atom of the former carbon-carbon double bond. The transition metal catalyst comprises a Group 8 metal and a ligand containing one or more 2-electron donor atoms. The present invention is also directed to enantioselective reactions of amine compounds with compounds containing carbon-carbon double bonds, and a calorimetric assay to evaluate potential catalysts in these reactions.
Allylic Amination Promoted by Copper
Baruah, Jubaraj B.,Samuelson, Ashoka G.
, p. 9449 - 9454 (2007/10/02)
A mild method for the synthesis of allylic amines by using a mixture of copper(II)perchlorate and copper metal is described.
Irradiation of 1,3-Dienes in the Presence of Anilines
Culp, Sandra J.,Bednar, William M.,Pienta, Norbert J.
, p. 3953 - 3955 (2007/10/02)
Acetonitrile solutions of 1,3-cyclohexadiene or 2,5-dimethyl-2,4-hexadiene and aniline, its N-methylated derivatives, Et2NH, or Et3N were irradiated at 350 nm.Adducts (3-anilinoalkenes) were observed in the presence of the primary or secondary anilines but not with the tertiary aniline or the alkylamines.The products are interpreted as arising via an electron-transfer intermediate within the singlet manifold.The cyclic diene gives competitive and dimerization apparently via the triplet.A third diene cyclooctadiene gave no observable chemistry in appreciable amounts.
