536992-87-7

Upstream product

• 637-87-6 1-Chloro-4-iodobenzene 
• 17906-63-7 trimethyl(5-methylhex-1-yn-1-yl)silane 
• 796055-89-5 (E)-1-trimethylsilyl-1-tributylstannyl-5-methyl-1-hexene 

Relevant academic research and scientific papers

A facile stereoselective synthesis of (E)-α-silylvinylstannanes via hydromagnesiation of alkynylsilanes

(E)-α-Silylvinylstannanes have been synthesized by the hydromagnesiation reaction of alkynylsilanes, followed by the reaction with trialkylstannyl chlorides. (E)-α-Silylvinylstannanes can undergo the cross-coupling reaction with aryl iodides in the presence of a catalytic amounts of Pd(PPh3)4 and CuI to afford (Z)-1,2-disubstituted vinylsilanes in good yields.

Alkynylsilanes as convenient precursors for the stereoselective synthesis of (E)-disubstituted alkenes

Hydromagnesiation of alkynylsilanes 1 gives (Z)-α-silylvinyl Grignard reagents 2, which are reacted with alkyl iodides or aryl iodides in the presence of Cul or Pd(PPh3)4 catalysts to afford (Z)-1,2-disubstituted vinylsilanes 3 in good yields. Intermediates 3 can undergo a desilylation reaction to give (E)-disubstituted alkenes 4 in high yields.