537-24-6

Basic information

• Product Name: 3,5-dibromotyrosine
• CAS NO: 537-24-6
• Molecular Formula: C₉H₉Br₂NO₃
• Molecular Weight: 338.982
• EINECS: 208-661-9
• Mol File: 537-24-6.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: 3,5-dibromotyrosine(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-dibromotyrosine(537-24-6)
• EPA Substance Registry System: 3,5-dibromotyrosine(537-24-6)

Safety Data

• Hazardous Substances Data: 537-24-6(Hazardous Substances Data)

Usage

General Description

3,5-Dibromotyrosine is a chemical compound formed from the amino acid tyrosine that contains two bromine atoms at positions 3 and 5 of the tyrosine molecule. It is commonly found in marine organisms such as sponges and algae, where it is believed to play a role in defense mechanisms against predators and pathogens. 3,5-Dibromotyrosine has also been studied for its potential antioxidant and anti-inflammatory properties, making it a subject of interest in pharmaceutical and biomedical research. Additionally, it has been investigated for its potential use in the development of new drugs for the treatment of cancer and other diseases.

Upstream product

• 300-38-9 3,5-dibromo-L-tyrosine 
• 60-18-4 L-tyrosine 
• 556-02-5 ?Tyr 

Downstream Products

• 765952-41-8 methyl 7-hydroxy-1,2,3,4-tetrahydroisoquinoline-3-carboxylate 
• 80527-48-6 2,2,3,3,4,4,4-Heptafluoro-butyric acid 2,6-dibromo-4-[2-(2,2,3,3,4,4,4-heptafluoro-butyrylamino)-2-methoxycarbonyl-ethyl]-phenyl ester 
• 556-02-5 ?Tyr 
• 61039-29-0 2-Amino-3-(3,5-dibromo-4-hydroxy-phenyl)-propionic acid methyl ester; hydrochloride 

Relevant articles and documents

Discovery of pyridine tetrahydroisoquinoline thiohydantoin derivatives with low blood-brain barrier penetration as the androgen receptor antagonists

Prostate cancer (PC) is the most diagnosed type of malignancy in men and the major frequently cause of cancer-related death worldwide. The androgen receptor (AR) has become a promising drug target for the treatment of PC. Here, we reported the design, optimization and evaluation of pyridine tetrahydroisoquinoline thiohydantoin derivatives with improved activity and safety as potent AR antagonists. The most promising compound 42f exhibited potent inhibitory activity on AR and strongly blocked AR nuclear translocation. Moreover, 42f displayed promising in vitro antitumor activity toward AR-dependent prostate cancer cell lines (LNCaP) and also demonstrated therapeutic effects in LNCaP xenograft tumor model in mice (TGI: 79%) with no apparent toxicity observed in vivo. More importantly, 42f showed negligible penetration of the brain-blood barrier (BBB) compared with enzalutamide. These results provide a foundation for the development of a new class of androgen receptor antagonists for potential therapeutics against PC with lower seizurogenic risk for patients.

Composition of matter having bioactive properties

Particles of coordinated complex comprising a basic, hydrous polymer and a capacitance adding compound, as well as methods for their production, are described. These complexes exhibit a high degree of bioactivity making them suitable for a broad range of applications through their incorporation into conventional vehicles benefiting from antimicrobial and similar properties.