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Tyrosine, N-acetyl-methyl ester, also known as N-acetyl-L-tyrosine methyl ester, is a synthetic derivative of the amino acid tyrosine. It is characterized by the acetylation of the amino group and the methylation of the carboxylic acid group. Tyrosine, N-acetyl-, methyl ester is often used in biochemical research and pharmaceutical development due to its potential applications in studying enzyme activity and as a building block for the synthesis of more complex molecules. The chemical structure of N-acetyl-L-tyrosine methyl ester is C11H13NO4, with a molecular weight of 223.22 g/mol. It is a white crystalline solid that is soluble in water and various organic solvents. The compound is synthesized through a series of chemical reactions, typically involving the protection of the amino and carboxylic acid groups of tyrosine, followed by the introduction of the acetyl and methyl ester groups. This derivative is of interest in the field of medicinal chemistry, particularly in the development of drugs targeting tyrosine kinase enzymes, which play a crucial role in various signaling pathways and are implicated in numerous diseases.

23525-90-8

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23525-90-8 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 23525-90-8 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,3,5,2 and 5 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 23525-90:
(7*2)+(6*3)+(5*5)+(4*2)+(3*5)+(2*9)+(1*0)=98
98 % 10 = 8
So 23525-90-8 is a valid CAS Registry Number.

23525-90-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name l-N-acetyl tyrosine methyl ester

1.2 Other means of identification

Product number -
Other names methyl N-acetyl-tyrosinate

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:23525-90-8 SDS

23525-90-8Relevant academic research and scientific papers

Photoinduced Vitamin B12-Catalysis for Deprotection of (Allyloxy)arenes

Giedyk, Maciej,Turkowska, Joanna,Lepak, Sandra,Marculewicz, Marcin,ó Proinsias, Keith,Gryko, Dorota

supporting information, p. 2670 - 2673 (2017/05/24)

Vitamin B12 is a natural cobalt complex that, while reduced to the "supernucleophilic" Co(I) form, can easily react with electrophiles via an SN2 mechanism. It is also shown to react via an SN2′ mechanism with allylic compounds allowing for photochemical deprotection of (allyloxy)arenes. A sustainable alternative to commonly used noble metal-catalyzed deprotection reactions is presented.

INTERMEDIATE COMPOUND WHICH IS USED FOR THE PREPARATION OF PIOGLITAZONE

-

Paragraph 0068, (2008/06/13)

The present invention relates to a novel compound of formula (IV) which is an intermediate that can be used for the preparation of pioglitazone. It also relates to a method of obtaining the novel compound (IV) starting from the natural product L-tyrosine, in which the amino group is protected in the form of aromatic imino group, and a method of obtaining pioglitazone from the said intermediate.

ANTI-ODOR COMPOSITIONS AND THERAPEUTIC USE

-

, (2008/06/13)

This application discloses a composition comprising a malodor compound and an anti-odor ingredient effective for reducing the presence or production of malodor. The composition may be topically applied to a subject and is useful for cosmetic conditions, pharmaceutical indications, or other objectives.

A mild, highly selective and remarkably easy procedure for deprotection of aromatic acetates using ammonium acetate as a neutral catalyst in aqueous medium

Ramesh,Mahender,Ravindranath,Das, Biswanath

, p. 1049 - 1054 (2007/10/03)

Ammonium acetate was found to catalyze efficiently the selective deprotection of aromatic acetates in the presence of various sensitive functionalities in aqueous methanol under neutral conditions at room temperature to yield the corresponding phenols in excellent yields. The method has been utilized for deprotection of acetates of several naturally occurring bioactive phenolic compounds and for preparation of venkatasin, a natural coumarino-lignan, from the anticancer compound cleomiscosin A.

N-METHOXYDIACETAMIDE: A NEW SELECTIVE ACETYLATING AGENT

Kikugawa, Yasuo,Mitsui, Kimiyo,Sakamoto, Takeshi,Kawase, Masami,Tamiya, Hiroshi

, p. 243 - 246 (2007/10/02)

A simple and efficient method for the direct chemoselective acetylation of primary amines in the presence of alcohols or secondary amines using a new reagent N-methoxydiacetamide is described.

Octapeptides and methods for their production

-

, (2008/06/13)

New octapeptides having the formula Prot Grp-R-Trp-Ser-Tyr-R2 -Leu-Arg-Pro-R3 ; salts thereof; wherein R is Gln, Gln (bzl), His (bzl), Ser (bzl), Pro, Leu, Tyr (bzl), Ile, Cys (bzl) or Phe, R2 is D-Phe, D-Ala, D-Leu, D-Trp, D-Tyr, D-Tyr (Me), D-Ser, D-Met, D-Arg, D-Val, D-His, D-Gln, D-Phs, D-Thr, D-Pro, D-Me5 Phe or D-Asn and R3 is NH2, NH(lower alkyl), N-(lower alkyl)2, NH-benzyl, NHCH2 CH2 N-(lower alkyl)2 or NH-CH2 CH2 SO2 NH-benzyl; methods for their production; certain peptide intermediates and their salts used in the production thereof; and the use of said octapeptides as luteinizing hormone releasing factor antagonists.

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