537041-16-0Relevant academic research and scientific papers
Synthesis and biological evaluation of spongistatin/altohyrtin analogues: E-ring dehydration and C46 side-chain truncation
Paterson, Ian,Acena, Jose L.,Bach, Jordi,Chen, David Y.-K.,Coster, Mark J.
, p. 462 - 463 (2003)
Simplified analogues of the potent antimitotic marine macrolide spongistatin 1/altohyrtin A were synthesised and evaluated as growth inhibitory agents against a range of human tumour cell lines, including Taxol-resistant strains, revealing that E-ring deh
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acena, Jose L.,Bach, Jordi,Wallace, Debra J.
, p. 2431 - 2440 (2007/10/03)
The antimitotic marine macrolide altohyrtin A/spongistatin 1 (1) has been synthesised in a highly convergent and stereocontrolled manner, thus contributing to the replenishment of the largely exhausted material from the initial isolation work. Coupling of
