53707-97-4Relevant academic research and scientific papers
Structure-activity relationship of anti-malarial spongean peroxides having a 3-methoxy-1,2-dioxane structure
Kawanishi, Motoyuki,Kotoku, Naoyuki,Itagaki, Sawako,Horii, Toshihiro,Kobayashi, Motomasa
, p. 5297 - 5307 (2007/10/03)
In order to study the structure-activity relationship of anti-malarial spongean peroxides, several analogues concerning with the 6-methoxyacetyl moiety and the 3-pentyl residue in methyl 2-(3-methoxy-3-pentyl-1,2-dioxan-6-yl) acetate were synthesized and evaluated for anti-malarial activity. In order to study the structure-activity relationship of anti-malarial spongean peroxides, several analogues concerning with the 6-methoxyacetyl moiety and the 3-pentyl residue in methyl 2-(3-methoxy-3-pentyl-1,2-dioxan-6-yl)acetate were synthesized and evaluated for anti-malarial activity. The tert-butyl ester analogue 14 showed stability in mouse serum and a high selectivity index against the malaria parasite, Plasmodium falciparum, and the citronellyl analogue 31 exhibited the strongest in vitro anti-malarial activity among them, and the imidazole analogue 25 showed desirable in vivo anti-malarial activity against P. berghei infected mice.
Pd(0)-Catalyzed Conjugate Addition of Benzylzinc Chlorides to α,β-Enones in An Atmosphere of Carbon Monoxide: Preparation of 1,4-Diketones
Yuguchi, Motoki,Tokuda, Masao,Orito, Kazuhiko
, p. 908 - 914 (2007/10/03)
Pd(0)-catalyzed conjugate addition of benzylzine chloride to methyl vinyl ketone in the presence of chlorotrimethylsilane and lithium chloride in an atmosphere of carbon monoxide at room temperature afforded 1-phenyl-2,5-hexanedione monosilyl enol ether. In this catalytic carbonylation, four components are connected in one reaction. Successive acidic workup generated a variety of 1,4-diketones from substituted benzylzine chlorides or related compounds and α,β-enones. Some products were converted to cyclopentenones or five-membered heterocyclic compounds containing an N, O, or S atom.
Switching between Novel Samarium(II)-Mediated Cyclizations by a Simple Change in Alcohol Cosolvent
Hutton, Thomas K.,Muir, Kenneth W.,Procter, David J.
, p. 4811 - 4814 (2007/10/03)
(Equation Presented) γ,δ-Unsaturated ketones undergo two very different stereoselective cyclization reactions mediated by samarium(II) iodide depending upon the alcohol cosolvent used in the reaction. Switching between an unprecedented aldol spirocyclizat
FACILE SYNTHESIS OF 2-SUBSTITUTED CYCLOPENTENONES
Baldwin, S. W.,Blomquist, H. R.
, p. 3883 - 3886 (2007/10/02)
An efficient synthesis of 2-substituted cyclopentenones is reported.Key reactions are the cyclopropanation of 2,2-dimethyl-3(2H)-furanone and subsequent conversion to the title compounds by oxidative fragmentation.
