53713-44-3

Upstream product

• 100-39-0 benzyl bromide 
• 97322-02-6 (6-hydroxy-2,5,7,8-tetramethyl-chroman-2-yl)-acetaldehyde 
• 78-70-6 3,7-dimethylocta-1,6-dien-3-ol 
• 121175-14-2 rac-3,4-dihydro-6-(phenylmethoxy)-2-(2-propenyl)-2,5,7,8-tetramethyl-2H-1-benzopyran 
• 53713-37-4 (6-benzyloxy-2,5,7,8-tetramethyl-chroman-2-yl)-acetic acid methyl ester 
• 1774-47-6 trimethylsulfoxonium iodide 
• 83057-18-5 (6-Benzyloxy-3,4-dihydro-2,5,7,8-tetramethyl-2H-1-benzopyran-2-yl)carboxaldehyde 
• 53101-73-8 methyl 2-(6-acetoxy-2,5,7,8-tetramethyl-3,4-dihydro-2H-benzo[1,2-b]pyran-2-yl)acetate 
• 163234-46-6 6-benzyloxy-2,5,7,8-tetramethyl-2-(4-methyl-pent-3-enyl)-chroman 
• 96909-75-0 (2RS)-6-benzyloxy-2,5,7,8-tetramethyl-2-(3-oxopropyl)chroman 
• 933474-06-7 (2RS)-2-(3'-acetoxyprop-2'-en-1'-yl)-6-benzyloxy-2,5,7,8-tetramethylchroman 
• 1983-71-7 (+/-)-3,4-dihydro-2,5,7,8-tetramethyl-2-(4-methyl-3-pentenyl)-2H-1-benzopyran-6-ol 
• 700-13-0 Trimethylhydroquinone 

Downstream Products

• 322472-13-9 4-O-benzyloxy-5R-[2R-(6-benzyloxy-2,5,7,8-tetramethylchroman-2(R,S)yl-methyl)-[1,3]dioxolan-4S-yl]-3-octadecyloxy-5H-furan-2-one 
• 322472-04-8 4-O-benzyloxy-5R-[2S-(6-benzyloxy-2,5,7,8-tetramethylchroman-2(R,S)yl-methyl)-[1,3]dioxolan-4S-yl]-3-octadecyloxy-5H-furan-2-one 
• 1254212-73-1 2,3:20,22-bis-O-[2-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)ethylidene]stachysterone 
• 1254212-71-9 2,3:20,22-bis-O-[2-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)ethylidene]-20-hydroxyecdysone 
• 1253967-65-5 2,3-O-[2-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)ethylidene]-20,22-O-isopropylidenestachysterone 
• 1253967-63-3 2,3-O-[2-(6-benzyloxy-2,5,7,8-tetramethylchroman-2-yl)ethylidene]-20,22-O-isopropylidene-20-hydroxyecdysone 
• 53713-38-5 rac-3,4-dihydro-2,5,7,8-tetramethyl-6-(phenylmethoxy)-2H-1-benzopyran-2-acetic acid 

Relevant academic research and scientific papers

Synthesis of α-tocopherol and naphthotocopherol analogs with a carboxyl group in the side chain

On the basis of ozonolysis of short-chain α-tocopherol and naphthotocopherol analogs with a terminal isopropylidene group in the side chain, a general approach to the synthesis of 6-hydroxy-2,5,7,8- tetrtamethylchroman-2-yl-and 6-hydroxy-2,5-dimethyl-3,4-

Neuroprotective agents having antioxidant and NMDA antagonist activity

The invention is directed to the use of novel compounds, compositions and methods for the prevention and treatment of neuronal tissue damage in mammals. The novel compounds comprise an antioxidant and a NMDA antagonist activity.

Novel antioxidant agents deriving from molecular combinations of vitamins C and E analogues: 3,4-Dihydroxy-5(R)-[2(R,S)-(6-hydroxy-2,5,7,8-tetramethyl-chroman-2(R,S)-yl-methyl)-[1,3]dioxolan-4(S)-yl]-5H-furan-2-one and 3-O-octadecyl derivatives

Molecular combinations of two antioxidants (i.e., ascorbic acid and the pharmacophore of α-tocopherol), namely the 2,3-dihydroxy-2,3-enono-1,4-lactone and the chromane residues, have been designed and tested for their radical scavenging activities. When evaluated for their capability to inhibit malondialdehyde (MDA) production in rat liver microsomal membranes, the 3,4-dihydroxy-5R-2(R,S)-(6-hydroxy-2,5,7,8-tetramethylchroman-2(R,S)yl-methyl)-1,3]dioxolan-4S-yl]-5H-furan-2-one (11a-d), exhibited an interesting activity. In particular the 5R,2R,2R,4S and 5R,2R,2S,4S isomers (11c,d) displayed a potent antioxidant effect compared to the respective synthetic α-tocopherol analogue (5) and natural α-tocopherol or ascorbic acid, used alone or in combination. Moreover, the mixture of stereoisomers 11a-d also proved to be effective in preventing damage induced by reperfusion on isolated rabbit heart, in particular at the higher concentration of 300 μM. In view of these results our study represents a new approach to potential therapeutic agents for applications in pathological events in which a free radical damage is involved. Design, synthesis and preliminary biological activity are discussed. Copyright (C) 2000 Elsevier Science Ltd.

Chromanemelonate esters

Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.

2-halochromans

Novel 2-halochromans and their coupling to various nucleophiles to produce Vitamin E and as well as novel intermediates for Vitamin E.

Antioxidant chroman compounds

The (6-hydroxy-chroman-2-yl) acetic or carboxylic acid derivatives useful as antioxidants and a method for preparing these derivatives from hydroquinones and intermediates in this synthesis as well as the use of these derivatives as intermediates in the preparation of optically active alpha-tocopherol.