53722-40-0Relevant academic research and scientific papers
Method for preparing amidine compound
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Paragraph 0086; 0093; 0096; 0107, (2017/07/23)
The invention relates to a method for preparing a compound shown in formula (I). The method comprises the following step: carrying out a compound shown in formula (V) and a compound shown in formula (IV) in the presence of a rhodium catalyst in an inert atmosphere to obtain the compound shown in formula (I). According to the method, amidine compounds with different substituents are obtained by virtue of a process of catalysis of a transition metal rhodium with relatively high stability to water and oxygen under a certain reaction condition, the reaction raw materials are simple and highly available, reaction has relatively high tolerance and universality to functional groups, and the method can be widely used for preparing the amidine compounds with different substituents.
Tandem Coupling of Azide with Isonitrile and Boronic Acid: Facile Access to Functionalized Amidines
Zhang, Zhen,Huang, Baoliang,Qiao, Guanyu,Zhu, Liu,Xiao, Fan,Chen, Feng,Fu, Bin,Zhang, Zhenhua
supporting information, p. 4320 - 4323 (2017/04/04)
Amidine is a notable nitrogen-containing structural motif found in bioactive natural products and pharmaceuticals. Herein, a novel rhodium(I)-catalyzed tandem reaction of readily accessible azides with isonitriles and boronic acids via a carbodiimide intermediate is achieved. This protocol offers an alternative approach toward N-sulfonyl-, N-acyl-, and N- phosphoryl-functionalized, as well as general N-aryl and N-alkyl amidines with broad substrate scope. In addition, functionalized guanidines can also been synthesized when amines are used instead. The accomplishment of estrone-derived amidine and glibenclamide bioisosteres further reveals the practical utility of this strategy.
Charge Effects in PCP Pincer Complexes of NiII bearing Phosphinite and Imidazol(i)ophosphine Coordinating Jaws: From Synthesis to Catalysis through Bonding Analysis
Vabre, Boris,Canac, Yves,Lepetit, Christine,Duhayon, Carine,Chauvin, Remi,Zargarian, Davit
supporting information, p. 17403 - 17414 (2016/01/25)
This contribution reports on a new family of NiII pincer complexes featuring phosphinite and functional imidazolyl arms. The proligands RPIMCHOPR′ react at room temperature with NiII precursors to giv
